548 results found
    1. Chromosomes and Gene Expression

    Gene regulation: A transcriptional switch controls meiosis

    A Elizabeth Hildreth, Karen M Arndt
    A key protein involved in the segregation of meiotic chromosomes is produced 'just in time' by the regulated expression of two mRNA isoforms.
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    1. Chromosomes and Gene Expression

    YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci

    Yuichi Shichino et al.
    A YTH-domain protein Mmi1 prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice

    Sona Gregorova et al.
    Prdm9-generated meiotic asynapsis of homologous chromosomes in mouse subspecific hybrids causes hybrid sterility and can be reversed by introducing random stretches of consubspecific sequence (≥ 27Mb) on four chromosomes most sensitive to asynapsis.
    1. Chromosomes and Gene Expression

    Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis

    David V Phizicky et al.
    Meiotic cells inhibit two distinct steps of replisome assembly with multiple kinases to prevent DNA replication between Meiosis I and Meiosis II.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    wtf genes are prolific dual poison-antidote meiotic drivers

    Nicole L Nuckolls et al.
    Selfish wtf meiotic drive genes use overlapping transcripts to encode both a trans-acting poison to kill gametes that do not inherit the gene and a gamete-autonomous antidote to specifically rescue the gametes that do.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila

    Cathleen M Lake et al.
    The Zip3-like protein Vilya links the initiation of meiotic recombination with crossover formation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The asymmetry of female meiosis reduces the frequency of inheritance of unpaired chromosomes

    Daniel B Cortes et al.
    Female meiotic spindles correct trisomy by expelling extra chromosomes into the first polar body.
    1. Genetics and Genomics

    Recombination, meiotic expression and human codon usage

    Fanny Pouyet et al.
    Variation in codon usage among functional categories of human genes is not due to selection for translation efficiency, but to differences in intragenic recombination rate, linked to variation in meiotic transcription level.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Single-molecule observation of DNA compaction by meiotic protein SYCP3

    Johanna L Syrjänen et al.
    Building on previous work (Syrjänen, Pellegrini, & Davies, 2014), it is shown that SYCP3 contributes to the architecture of meiotic chromosomes through local bridging interactions that result in large-scale compaction of the chromosome axis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors

    Ofer Rog et al.
    Formation of a phase-separated interface between homologous chromosomes during meiosis enables regulatory signals to spread in cis over long distances, illuminating the longstanding mystery of crossover interference.

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