1,735 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains

    Rachael E Barton, Lucia F Massari ... Adèle L Marston
    Meiotic recombination and chromosome segregation require the establishment of chromatin boundaries by the acetyltransferase Eco1, which anchors both chromatin loops and cohesion.
    1. Chromosomes and Gene Expression

    The kinetochore prevents centromere-proximal crossover recombination during meiosis

    Nadine Vincenten, Lisa-Marie Kuhl ... Adèle L Marston
    The meiotic DNA recombination landscape is locally influenced by the kinetochore to minimize potentially deleterious pericentromeric crossover recombination.
    1. Cell Biology
    2. Developmental Biology

    SUMO is a pervasive regulator of meiosis

    Nikhil R Bhagwat, Shannon N Owens ... Neil Hunter
    Multi-dimensional global proteomics describes the SUMO-modified proteome during meiosis and reveals novel roles in regulating the key events of meiotic chromosome metabolism.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice

    Mina L Kojima, Dirk G de Rooij, David C Page
    The switch from mitotic cell cycles to the one meiotic cell cycle in each generation is triggered through dramatic upregulation of a broad gene expression program by transcriptional regulator STRA8.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    wtf genes are prolific dual poison-antidote meiotic drivers

    Nicole L Nuckolls, María Angélica Bravo Núñez ... Sarah E Zanders
    Selfish wtf meiotic drive genes use overlapping transcripts to encode both a trans-acting poison to kill gametes that do not inherit the gene and a gamete-autonomous antidote to specifically rescue the gametes that do.
    1. Chromosomes and Gene Expression

    Control of meiotic entry by dual inhibition of a key mitotic transcription factor

    Amanda J Su, Siri C Yendluri, Elçin Ünal
    Investigation of how cells rewire their transcriptional programs during transition from mitotic to meiotic cell fate reveals a two-pronged mechanism for inactivating a key mitotic transcription factor.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast

    Sarah E Zanders, Michael T Eickbush ... Harmit Singh Malik
    Rapid acquisition of chromosome rearrangements, together with independently acting transmission distorter alleles on each chromosome, drive near complete sterility in fission yeast hybrids.
    1. Cell Biology

    Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes

    S Zachary Swartz, Hieu T Nguyen ... Arminja N Kettenbach
    Time-course phosphoproteomics reveals that selective dephosphorylation is critical for directing the MI/MII transition and that, through its inherent phospho-threonine preference, PP2A-B55 imposes specific phosphoregulated behaviors that distinguish the two meiotic divisions.
    1. Cell Biology
    2. Genetics and Genomics

    Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage

    Regina Rillo-Bohn, Renzo Adilardi ... Abby F Dernburg
    Investigation of meiosis in the nematode Pristionchus pacificus has illuminated evolutionary variation in this essential aspect of reproduction and established a new model for future study.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    ATR/Mec1 prevents lethal meiotic recombination initiation on partially replicated chromosomes in budding yeast

    Hannah G Blitzblau, Andreas Hochwagen
    During meiosis, budding yeast use a checkpoint involving the protein Mec1 to prevent the formation of double-strand breaks in DNA that has not completed replication.

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