Detailed analysis of the sequence of monocyte differentiation into distinct gut tissue macrophages provides insights into monocyte biology and can serve as a platform for the design of cell therapies.

Monocytes display distinct migratory and functional activity compared to dendritic cells and alveolar macrophages in the lungs.

Malaria remodels the spleen to imprint tolerance and reduce pathology in subsequent infections.

Notch signaling alters TLR-induced inflammation by skewing monocyte cell fate toward patrolling monocyte differentiation at the expense of macrophage cell fate.

The expression of DECTIN-2 family C-type lectin receptors on macrophages and monocytes is inhibited by the Th2 cytokine IL-4, which suggests a mechanism for inhibition of Th17 responses to MINCLE-dependent vaccination responses by underlying helminth infection.

Macrophage dynamics are fundamentally different between two commonly used inbred mouse strains and differences in local resident cell expansion versus monocyte recruitment determine the outcome of tissue nematode infection.

Resident dermal Mφ are programmed locally, independently of bone-marrow monocytes during Staphylococcus aureus infection, leading to transiently increased resistance, which is limited by a decrease in macrophage life span.

Diet-induced obesity in mice led to a duration of diet-dependent bone marrow adipocyte whitening, which drove monocyte expansion and skewing towards a tissue-invasive phenotype, likely contributing to ensuing tissue infiltration that accompanies obesity and diabetes.

Mechanistic insights show how treatment with apoA1 is anti-inflammatory by rapidly disrupting macrophage chemotaxis and monocyte recruitment.

A novel therapy for a common blinding retinal disease uses an innovative CCR1 blocking-based strategy.