A dimensional approach to psychiatry demonstrates the specificity and generalizability of a neurocognitive marker of compulsive behavior and intrusive thought via large-scale online testing.

Patients diagnosed with a cardiovascular disease are at higher risk of psychiatric disorders, independent of familial factors shared between full siblings and comorbid conditions.

Asymmetric activation of the dysgranular mid-insula during interoceptive processing contributes to disrupted bodily awareness in individuals with anxiety, depression, and eating disorders.

A population-based analysis demonstrates that surviving twins who lose their co-twins by death are at considerably elevated risks of developing psychiatric disorders.

The multimodal linked independent component analysis promotes a more integrative understanding of transdiagnostic mechanisms of psychopathology.

Findings of this population-based sibling-matched cohort study corroborate an association of loss of a co-twin at birth with risk of psychiatric disorders, supporting the hypothesis of twin-bond development in utero.

Human neuroimaging and machine learning reveals a generalizable relationship between brain connectivity and working memory ability across healthy populations and distinct psychiatric diagnoses.

A novel methodical approach aimed at improving translation of network analyses to psychopathology provides an intuitive representation of longitudinal clinical pathways between symptoms and can assist in predicting prognosis.

Self-esteem, the value that people ascribe to the self, is represented in the ventromedial prefrontal cortex and dynamically updated when people learn how others value them.

Structural differences in adolescent brains associated with binge drinking might be preceding the onset of such behavior, suggesting a reevaluation of studies of the effects of alcohol on the adolescent brain.