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    1. Cell Biology

    Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity

    Mario Ruiz et al.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

    Masahiro Oka et al.
    A key molecule that connects leukemogenic proteins to aberrant HOX gene regulation turned out to be a nuclear export factor, CRM1.
    1. Cell Biology
    2. Plant Biology

    From plasmodesma geometry to effective symplasmic permeability through biophysical modelling

    Eva E Deinum et al.
    1. Cell Biology
    2. Genetics and Genomics

    The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

    Heather P Harding et al.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A microtranslatome coordinately regulates sodium and potassium currents in the human heart

    Catherine A Eichel et al.
    Association of mRNA in discrete, cotranslational complexes regulates currents controlling excitability in human cardiomyocytes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Profilin and formin constitute a pacemaker system for robust actin filament growth

    Johanna Funk et al.
    Profilin release from the filament end controls the speed of actin growth at physiological conditions.
    1. Cell Biology
    2. Developmental Biology

    Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila

    Nicanor González-Morales et al.
    1. Cell Biology

    Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

    Rui Jia, Juan S Bonifacino
    An ensemble of the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin-ligase BIRC6 mediates ubiquitination of LC3, targeting the latter for proteasomal degradation and thus attenuating autophagic degradation of cellular substrates.
    1. Cancer Biology
    2. Cell Biology

    Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

    Hao Zeng et al.
    1. Cell Biology
    2. Neuroscience

    A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency

    Xiao Min Zhang et al.
    In mammals, the vesicular glutamate transporter 1 acquired a proline-rich sequence that negatively regulates the spontaneous release of glutamate by reducing the exchange of synaptic vesicles along the axon.
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