Browse our latest Cell Biology articles

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    1. Cell Biology
    2. Genetics and Genomics

    Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

    Giulia Ambrosi et al.
    Bi-allelic tagging enables the biophysical analysis of oncogenic β-catenin genetic variants in Wnt signaling.
    1. Cell Biology
    2. Developmental Biology

    Nano-scale architecture of blood-brain barrier tight-junctions

    Esther Sasson et al.
    Super-resolution imaging uncovers sparse occludin vs. clustered ZO1/claudin-5 architecture, and claudin-5 arrangement compacting during blood-brain-barrier tight-junction (TJ) maturation in which TJs become first restrictive to large and later to small molecules.
    1. Cell Biology

    Rapid genome editing by CRISPR-Cas9-POLD3 fusion

    Ganna Reint et al.
    Novel Cas9 fusion with DNA polymerase delta subunit 3 (POLD3), identified via high-throughput screening of more than 450 DNA repair proteins, enhances editing by speeding up the initiation of DNA repair.
    1. Cell Biology

    Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

    Emanuel Rognoni et al.
    UV irradiation, a major cause of skin damage, leads to selective loss of fibroblasts from the upper dermis via a deregulated inflammatory response, and infiltrating T cells can promote fibroblast survival in UV irradiated skin.
    1. Cell Biology
    2. Evolutionary Biology

    Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

    Chirine Toufaily et al.
    The absence of a carboxy-terminal tail in the GnRH receptor is not required for the preovulatory luteinizing hormone surge and fertility in mammals.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

    Dylan Gerard Ryan et al.
    Multi-omic analyses reveal a connection between the integrated stress response and the regulation of redox and amino acid metabolism when the TCA cycle is impaired.