A conserved glucagon signaling pathway links high-fat diet-induced metabolic imbalance to cardiac arrhythmia through hormone-producing cells and heart-innervating neurons that regulate rhythmicity.
Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.
Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenetic-like gene control without photoreceptors.
