The apical polarity protein CRB3 is crucial for regulating vesicle trafficking in γ-tubulin ring complex assembly during ciliogenesis and cilium-related Hedgehog and Wnt signaling pathways in tumorigenesis.
Artur Ruppel, Dennis Wörthmüller ... Martial Balland
Combining micropatterning, traction force microscopy, and optogenetics, it is shown that epithelial cells actively respond to mechanical signals from neighboring cells.
Analysis of inositol pyrophosphate dynamics upon inorganic phosphate (Pi) starvation identifies 1,5-IP8 as the inositol pyrophosphate isomer signaling Pi sufficiency to the SPX domain of Pho81 that controls the transcriptional Pi starvation program.
