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    1. Cell Biology

    GTPase-activating protein DLC1 spatio-temporally regulates Rho signaling

    Lucien Hinderling, Max Heydasch ... Olivier Pertz
    Mechanosensitive recruitment of DLC1 to focal adhesions creates a positive feedback loop that locally amplifies Rho activation in response to tension.
    1. Cell Biology

    Specialisation of meiotic kinetochores revealed through a synthetic spindle assembly checkpoint strategy

    Lori B Koch, Tiasha Ghosh ... Adèle L Marston
    A system to enrich yeast in metaphase of mitosis, meiosis I, or meiosis II reveals reduced spindle assembly checkpoint robustness in meiosis I and distinct kinetochore composition and phosphorylation states.
    1. Cell Biology
    2. Developmental Biology

    Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension

    Hwa-seon Seo, Deli Yu ... Jianbo Wang
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

    Sunayana Sarkar, Harsha Sharma ... Manish Jaiswal
    A genetic toolkit establishes Drosophila as a tractable metazoan system for systematic interrogation of conserved biological functions of the ancient polymer polyphosphate.
    1. Cell Biology
    2. Neuroscience

    CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function

    Longxin Xie, Jessica Merjane ... Christopher J Donnelly
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology

    A Novel 3D Visualization Method in Mice Identifies the Periportal Lamellar Complex (PLC) as a Key Regulator of Hepatic Ductal and Neuronal Branching Morphogenesis

    Tongtong Xu, Fujun Cao ... Chengjian Zhao
    Revised
    Reviewed Preprint v4
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

    Lingli Kong, Ximena Zottig ... Nikolaus Grigorieff
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Neuroscience

    ATP8B1–TMEM30B Flippase Activity Maintains Stereocilia Lipid Asymmetry Required for Hearing

    Henry N De Hoyos, Sihan Li ... Jung-Bum Shin
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology

    Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity

    Elsa Meneses-Salas, Moises Castellá ... Albert Lu
    Dysregulated exocytosis of bis(monoacylglycerol)phosphate (BMP)-enriched extracellular vesicles driven by pathogenic LRRK2 activity supports elevated urinary BMP levels and its use as a biomarker for Parkinson's disease.
    1. Cell Biology

    Human receptive endometrial assembloid for deciphering the implantation window

    Yu Zhang, Rusong Zhao ... Han Zhao
    A specialized window-of-implantation endometrial assembloid enables investigation of human endometrial receptivity and maternal-fetal interaction.
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