Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Inflammasomes: A tale of two caspases

    Denise M Monack
    Macrophages control intracellular pathogens like Salmonella by using two caspase enzymes at different times during infection.
    Version of Record
    Insight
    1. Immunology and Inflammation
    2. Medicine

    Deciphering the preeclampsia-specific immune microenvironment and the role of pro-inflammatory macrophages at the maternal–fetal interface

    Haiyi Fei, Xiaowen Lu ... Lingling Jiang
    Multi-omics analysis shows that preeclampsia-specific immune cell network was regulated by Folr2+Ccl7+Ccl8+C1qa+C1qb+C1qc+ pro-inflammatory macrophages, which can induce the CD8+ and Th17 memory T cells generation while inhibiting the gMDSCs production.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

    Marisa S Egan, Emily A O'Rourke ... Sunny Shin
    Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.
    1. Immunology and Inflammation

    ImPaqT - A Golden Gate-based Toolkit for Zebrafish Transgenesis

    Saskia Hurst, Christiane Dimmler, Mark R Cronan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Immunology and Inflammation

    Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation

    Jian Cui, Hua Li ... Congqing Wu
    Procoagulant microvesicles derived from ruptured immune cells fuel blood coagulation.
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s disease

    Rocio Vicario, Stamatina Fragkogianni ... Frédéric Geissmann
    A subset of Alzheimer disease patients carry mutant microglia somatic clones which promote neuro-inflammation.
    1. Immunology and Inflammation

    Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

    Sytse J Piersma, Shasha Li ... Wayne M Yokoyama
    A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.
    1. Immunology and Inflammation

    The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020

    João Paulo Portela Catani, Anouk Smet ... Thorsten U Vogel
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Celldetective: an AI-enhanced image analysis tool for unraveling dynamic cell interactions

    Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid