It is proposed that innate immune cells are positioned to activate the naïve B cell repertoire and rational application of training stimuli could enforce this, offsetting original antigenic sin, wherein recall of ‘off-target’ B cell memory can obscure vaccine effectiveness.
Thomas Balligand, Claire Carpenet ... Maarten Dewilde
Two radio-labeled nanobodies and a single knock-in mouse model suffice to track the biodistribution of various unmodified cell-types in live mice by PET/CT.
Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.
Wesley H Godfrey, Judy J Lee ... Michael D Kornberg
The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanced than previously appreciated.
Hannah Riley Knight, Marie Kim ... Aaron Esser-Kahn
Current approaches in bioengineering are synthesized and methods for their implementation are suggested for the induction and modulation of trained immunity in the treatment of human diseases.
Both adaptive and innate immune memory responses have been described in gamma delta T cells, yet the mechanisms, the ligands and the gamma delta T cell subsets generating memory responses have remain to be explored.
