Specific host factors, such as immune cell activity, sex hormones and microbiota composition, influence the ability of Staphylococcus aureus bacteria to colonize the gut of mice.
During aging, microglia progress through intermediate cellular states, including stress response and translation upregulation states, that modulate subsequent activation and impact cognitive decline.
Mohsen Khosravi-Maharlooei, Andrea Vecchione ... Megan Sykes
Functional analyses identify Tfh-like and Tph-like CD4+ T cells as drivers of a spontaneous autoimmune syndrome characterized by autoreactive B cells in human immune system mice.
Disruption of RAS–p110α signalling in macrophages impairs both the initiation and resolution of inflammatory responses, revealing a critical regulatory role in immune function and inflammation control.
A MASLD mouse model reveals that gut-derived Gram-negative bacterial lipopolysaccharides promote hepatic lipid accumulation and acyloxyacyl hydrolase, a host lipase that degrades and inactivates lipopolysaccharides and mitigates MASLD.
Immune memory B cells in people with cystic fibrosis contain bacteria-specific sequences that could be used to make new treatments for life-threatening infections.
Germline V-gene usage can be inferred from cryoEM reconstructions of antigen-antibody complexes to guide de novo antibody sequencing of complex mixtures by mass spectrometry.
