The established under-flow migration tracker (UFMTrack) framework allows for automated and scalable studies of immune cell interactions with and extravasation across endothelial monolayer under flow in vitro.
Graham L Barlow, Christian M Schürch ... Paul L Bollyky
A high-parameter, spatial analysis of the pancreata of individuals with type 1 diabetes reveals specific patterns of immune infiltration into islets of Langerhans, coordinated with changes in the surrounding tissue.
Eugenio Antonio Carrera Silva, Juliana Puyssegur, Andrea Emilse Errasti
Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and extracellular vesicles.
Hella Luksch, Felix Schulze ... Angela Rösen-Wolff
TNF signaling contributes significantly to pathology of constitutively active STING in murine STING-associated vasculopathy with onset in infancy disease.
Gut microbiota composition and sex hormones influence the immune response to methicillin-resistant Staphylococcus aureus gastrointestinal colonization in mice.
Molecular dynamics simulations reveal that lipid binding at antibody loops and framework regions stabilizes membrane interactions, providing molecular details for neutralization mechanisms and strategies for HIV-1 vaccine development.
Ana Cristina Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
Recognition of antigenic ligand by T-cell receptors is a nuanced process where mechanical force can be leveraged to diversify functional outcomes of different T-cells for the same ligand.
CXXC1 is a pivotal epigenetic regulator that ensures Treg homeostasis and suppressive function by interacting with FOXP3 to modulate H3K4me3 deposition at key signature genes.
