Browse our latest Immunology and Inflammation articles

Adenosine produced by transmethylation may act as a sensor of the balance between cell activity and nutrient supply.

Recognition of antigenic ligand by T-cell receptors is a nuanced process where mechanical force can be leveraged to diversify functional outcomes of different T-cells for the same ligand.

CXXC1 is a pivotal epigenetic regulator that ensures T_reg homeostasis and suppressive function by interacting with FOXP3 to modulate H3K4me3 deposition at key signature genes.

Genetically diverse Mycobacterium tuberculosis complex strains induce a gamut of human granulomatous responses in vitro, with a role for IL-1β in aggregate formation.

Macrophages control intracellular pathogens like Salmonella by using two caspase enzymes at different times during infection.

Multi-omics analysis shows that preeclampsia-specific immune cell network was regulated by Folr2⁺Ccl7⁺Ccl8⁺C1qa⁺C1qb⁺C1qc⁺ pro-inflammatory macrophages, which can induce the CD8⁺ and Th17 memory T cells generation while inhibiting the gMDSCs production.

Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.