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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Innate immunity and training to subvert original antigenic sin by the humoral immune response

    Faez Amokrane Nait Mohamed, Daniel Lingwood
    It is proposed that innate immune cells are positioned to activate the naïve B cell repertoire and rational application of training stimuli could enforce this, offsetting original antigenic sin, wherein recall of ‘off-target’ B cell memory can obscure vaccine effectiveness.
    1. Immunology and Inflammation

    Beta-Glucan Modulates Monocyte Plasticity and Differentiation Capacity to Mitigate DSS-Induced Colitis

    Yinyin Lv, Yanyun Fan ... Hongzhi Xu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    • Convincing
    1. Immunology and Inflammation

    Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma

    Jo-Chiao Wang, Amelia Kulle ... Sebastien Talbot
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation

    DGKα and ζ Deficiency Causes Regulatory T-Cell Dysregulation, Destabilization, and Conversion to Pathogenic T-Follicular Helper Cells to Trigger IgG1-Predominant Autoimmunity

    Lei Li, Hongxiang Huang ... Xiao-Ping Zhong
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling

    Sung Hoon Cho, Shawna K Brookens ... Mark R Boothby
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation
    2. Medicine

    A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

    Thomas Balligand, Claire Carpenet ... Maarten Dewilde
    Two radio-labeled nanobodies and a single knock-in mouse model suffice to track the biodistribution of various unmodified cell-types in live mice by PET/CT.
    1. Immunology and Inflammation

    CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

    Liangliang Fu, Chenghu Yin ... Haibin Xia
    Targeting CD81+ fibroblasts–neutrophils axis provides a new strategy for periodontitis treatment.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Trained immunity in the lung

    Elina Idiiatullina, Dane Parker
    Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.
    1. Immunology and Inflammation

    Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

    Wesley H Godfrey, Judy J Lee ... Michael D Kornberg
    The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanced than previously appreciated.
    1. Immunology and Inflammation

    Bioengineering approaches to trained immunity: Physiologic targets and therapeutic strategies

    Hannah Riley Knight, Marie Kim ... Aaron Esser-Kahn
    Current approaches in bioengineering are synthesized and methods for their implementation are suggested for the induction and modulation of trained immunity in the treatment of human diseases.
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