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    1. Immunology and Inflammation

    Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

    Alexander J Knights, Easton C Farrell ... Tristan Maerz
    Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.
    1. Immunology and Inflammation

    DGKα and ζ Deficiency Causes Regulatory T-Cell Dysregulation, Destabilization, and Conversion to Pathogenic T-Follicular Helper Cells to Trigger IgG1-Predominant Autoimmunity

    Lei Li, Hongxiang Huang ... Xiao-Ping Zhong
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

    Benita Martin-Castaño, Patricia Diez-Echave ... Julio Galvez
    Biomarkers of COVID-19 severity identified in nasopharyngeal and faecal microbiota could improve prognostic accuracy and treatment strategies for severe cases.
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Newly discovered and conserved role of IgM against viral infection in an early vertebrate

    Weiguang Kong, Xinyou Wang ... Zhen Xu
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

    Adam Kim, Megan R McMullen ... Srinivasan Dasarathy
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome

    Yan Zhao, Hanshuo Zhu ... Li Sun
    T3SS translocon induces NLRC4-mediated cell death via a conserved C-terminal region shared by many T3SS-positive bacterial pathogens.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

    Xu Zheng, Shi Yu ... Guangxun Meng
    Interleukin-1 activates RhoA/ROCK signaling, which drives the enrichment of actin bundles at the cell-cell junctions, preventing SARS-CoV-2 spreading via syncytia formation.
    1. Immunology and Inflammation

    Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

    Ning Song, Hang Gao ... Wenlong Zhang
    Gut microbiota from young mice can alleviate gout and hyperuricemia in aged mice, further revealing that the metabolic product butyrate derived from the gut microbiota exerts similar therapeutic effects.
    1. Immunology and Inflammation

    Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges

    Weigao Zhang, Hu Liu ... Dan Weng
    Hepatocyte RIPK1 plays an important role in liver physiology, preventing liver injury and inflammation during metabolic stresses like acute fasting.
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