Browse our latest Immunology and Inflammation articles

During aging, microglia progress through intermediate cellular states, including stress response and translation upregulation states, that modulate subsequent activation and impact cognitive decline.

Functional analyses identify Tfh-like and Tph-like CD4⁺ T cells as drivers of a spontaneous autoimmune syndrome characterized by autoreactive B cells in human immune system mice.

Disruption of RAS–p110α signalling in macrophages impairs both the initiation and resolution of inflammatory responses, revealing a critical regulatory role in immune function and inflammation control.

Immune memory B cells in people with cystic fibrosis contain bacteria-specific sequences that could be used to make new treatments for life-threatening infections.

A MASLD mouse model reveals that gut-derived Gram-negative bacterial lipopolysaccharides promote hepatic lipid accumulation and acyloxyacyl hydrolase, a host lipase that degrades and inactivates lipopolysaccharides and mitigates MASLD.

Germline V-gene usage can be inferred from cryoEM reconstructions of antigen-antibody complexes to guide de novo antibody sequencing of complex mixtures by mass spectrometry.

Lipid nanoparticles containing microRNA-26-mimics can reduce MASH in mice, providing a novel therapeutic approach.

The established under-flow migration tracker (^UFMTrack) framework allows for automated and scalable studies of immune cell interactions with and extravasation across endothelial monolayer under flow in vitro.