Browse our latest Neuroscience articles

Page 121 of 596
    1. Computational and Systems Biology
    2. Neuroscience

    A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation

    Nikolaos Vardalakis, Amélie Aussel ... Fabien B Wagner
    Combining biophysically realistic hippocampal neurons with coupled phase oscillators that represent theta inputs enables probing the phase-dependent effects of neurostimulation on theta-nested gamma oscillations in normal and pathological states.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism

    Mengyuan Xu, Torben Neelands ... Merritt Maduke
    A combination of high-resolution structure determination, electrophysiology, and MD simulations reveal fundamental insight into the molecular function of voltage-gated chloride channels.
    1. Neuroscience

    Hippocampome.org 2.0 is a knowledge base enabling data-driven spiking neural network simulations of rodent hippocampal circuits

    Diek W Wheeler, Jeffrey D Kopsick ... Giorgio A Ascoli
    Hippocampome.org v1.0, a foundational classification system of hippocampal neuron types, has evolved into 2.0, which recenters the focus on new functionality to build real-scale, biologically detailed, data-driven computational simulations.
    1. Neuroscience

    Circuit-based intervention corrects excessive dentate gyrus output in the fragile X mouse model

    Pan-Yue Deng, Ajeet Kumar ... Vitaly A Klyachko
    Circuit-based intervention corrects irreconcilable excitability defects between dentate granule cells and mossy cells in Fmr1 knockout mice, representing a promising strategy to restore the dentate excitation/inhibition balance and circuit computations.
    1. Neuroscience

    SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

    Surya Chandra Rao Thumu, Monika Jain ... Narendrakumar Ramanan
    Serum response factor (SRF) deficient reactive astrocytes are neuroprotective in the mammalian brain.
    1. Neuroscience

    Hearing: Letting the calcium flow

    Régis Nouvian
    Two calcium-binding proteins, CaBP1 and CaBP2, cooperate to keep calcium channels in the hair cells of the inner ear open.
    Version of Record
    Insight
    1. Cell Biology
    2. Neuroscience

    O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans

    Dilip Kumar Yadav, Andrew C Chang ... Christopher V Gabel
    The specific metabolic pathways that increase neuron regeneration in ogt-1 mutant C. elegans following in vivo laser axotomy, highlighting the potential power for such metabolic targets in the treatment of neuronal injury.
    1. Neuroscience

    RatInABox, a toolkit for modelling locomotion and neuronal activity in continuous environments

    Tom M George, Mehul Rastogi ... Caswell Barry
    A new python package standardises and simplifies how spatial behaviour and neural representations are modelled in continuous environments.
    1. Neuroscience

    A spatial-attentional mechanism underlies action-related distortions of time judgment

    Liyu Cao
    The distribution of visuospatial attention shapes the timing report results obtained with the Libet clock method, thus explaining the temporal binding effect in this context.
    1. Neuroscience

    Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model

    Andrew S Blaeser, Jun Zhao ... Dan Levy
    Functional imaging of individual sensory afferents that innervate the cranial meninges in a mouse migraine model reveals heightened responsiveness to movement-related meningeal deformations that may underlie headache.