By combining direct presynaptic patch-clamp electrophysiology and super-resolution microscopy, it was found that KO of RIM-BP2 reduced calcium channel abundance in hippocampal mossy terminals.
Sina B Kirchhofer, Victor Jun Yu Lim ... Moritz Bünemann
The molecular pattern underlying the interactions of opioids with their receptor determines whether membrane depolarization increases or decreases their response or even convert antagonists to agonists.
An atlas of cortical expression for 20,781 genes in the adult human brain, validated against multiscale datasets, from neuroimaging measures of structure and function to molecular cell and layer markers.
Barcoded rabies virus tracing combined with single-cell RNAseq and in situ sequencing achieves high-throughput retrograde projection mapping and synaptic connectivity mapping at cellular resolution.
Fibro-adipogenic progenitors in skeletal muscle contribute to the neuromuscular pathogenesis of spinal muscular atrophy, and depletion of SMN in chondrocytes reduces local IGF sigaling in growth plate.
Cortical network model suggests a mechanism explaining the link between NMDAR synaptic and spike synchrony deficits observed in a pharmacological monkey model of prefrontal network failure in schizophrenia.
Reto B Cola, Diana M Roccaro-Waldmeyer ... Marco R Celio
Foxb1-expressing hypothalamic neurons in the parvafox nucleus and the dorsal premammillary nucleus both contribute to behavioral and physiological components associated with defensive behavior.
Expression of the appropriate repertoire of membrane channels, essential for activity of flight-promoting central dopaminergic neurons of Drosophila, requires store-operated Ca2+ entry during late pupal development and early adults.
