Francisco Muñoz-Carvajal, Nicole Sanhueza ... Felipe A Court
Age-related epigenetic regulation of mitochondrial stress responses drives neuronal degeneration and sensory decline, highlighting mitochondrial resilience as a potential target to preserve brain function during aging.
Humans’ flexible temporal cognition, including mental time travel, arises from perspective-agnostic encoding of event sequences in the hippocampus and perspective-dependent retrieval and reconstruction in the posterior parietal cortex.
High levels of circulating estradiol enable the RP3V kisspeptin neuron population to exhibit long-lasting synchronized oscillatory behavior that drives GnRH neurons to initiate the LH surge.
Continuous flash suppression reduces V1 orientation responses in an ocular-dominance-dependent manner, which may still allow low-level coarse orientation discrimination but provide insufficient information for higher-level visual and cognitive tasks.
Alicja Monaghan, Richard AI Bethlehem ... Duncan E Astle
Contrary to prior work, principal axes of structural and functional connectivity are established early in life, remaining stable and undergoing refinement throughout development.
Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
Human stem cell-derived adherent cortical organoids in 384-well plates provide a reproducible, long-term cortical organoid platform with neurons, glia, and robust network activity, enabling scalable disease modeling and therapeutic screening.
