Rab10 deficiency unexpectedly inhibits neuropeptide secretion through two distinct effects on the endoplasmic reticulum (ER), disrupting ER-regulated intracellular Ca²⁺ dynamics and impairing protein synthesis.
By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.
The peripherally restricted opioid receptor antagonist naloxone methiodide reverses fentanyl-induced respiratory depression without causing aversive behaviors that are observed after naloxone.
David C Williams, Amanda Chu ... Michael A McDannald
A more complete, bidirectional relationship between fear conditioning and behavior is established when many behaviors are examined, as opposed to single behavior such as freezing.
