Maryna Pilkiw, Nathan Insel ... Kaori Takehara-Nishiuchi
Neuron populations in the lateral entorhinal cortex discriminate between memory-based contexts through both continuous "tonic" activity patterns as well as by their stimulus-evoked "phasic" responses.
Rat orbitofrontal cortex is required to accurately represent outcome distributions, whereas basolateral amygdala is necessary for the facilitation of learning in response to surprising events.
Connectomic reconstruction combined with activity imaging uncovered a rhythmically active neuronal circuit for the coordination of ciliary activity across the whole body of a marine larva.
After mating, female mice form a sensory memory of the stud male's pheromones that correlates with striking changes in responsiveness of the specific neural ensemble activated by her partner.
John P Grogan, Demitra Tsivos ... Elizabeth J Coulthard
Memory over 24 hours was impaired in Parkinson's patients off, rather than on, dopaminergic medication during reinforcement learning, whereas dopamine did not affect positive and negative reinforcement, in contrast to previous studies.
The subcortical visual pathway through the midbrain superior colliculus is responsible for visually evoked Pavlovian conditioning and dopamine neuron responses with predicted value in monkeys, which remained after lesioning V1.
Oligomeric Amyloid-β and Tau, two proteins involved in Alzheimer's disease pathogenesis, require Amyloid Precursor Protein to enter neurons and exert their detrimental effect on synaptic plasticity and memory.
Philipp Janz, Niels Schwaderlapp ... Carola A Haas
Non-invasive imaging of hippocampal neurodegeneration and structural reorganization during epileptogenesis allows the prediction of disease severity in mesial temporal lobe epilepsy, which may facilitate the early pharmacological intervention before seizure onset.
