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A novel region in the CaV2.1 α1 subunit regulates coupling of synaptic vesicles to CaV2.1 calcium channels, synaptic vesicle release and docking, and the size of the fast and total releasable pools of synaptic vesicles.

Sequential neuromodulation by acetylcholine and dopamine enables correlational synaptic learning which, when incorporated into a computational model, yields effective navigation toward changing reward locations as in natural foraging behavior.

The smoking cessation drug varenicline (Chantix) and other weak base ligands reduce a4b2-type nicotinic receptor (a4b2R) upregulation through slow intracellular release due to selective trapping in acidic vesicles that contain a4b2Rs.

The neural population of the Aplysia's pedal ganglion are a low-dimensional spiral attractor, and the parameters of the attractor directly define the properties of the Aplysia's escape locomotion behaviour.

A decoding-based, state-space reconstruction reveals that neurons in macaque IT cortex change the structure of their collective attractor dynamics depending on task contexts.

The APP intracellular domain (AICD) physiologically regulates synaptic GluN2B-containing NMDA receptor current, a process that could contribute to pathological Alzheimer's disease-related synaptic failure upon increase of AICD levels in adult neurons.

Excitotoxicity driven by NMDA receptor hyper-activation does not involve DAPK1-dependent events in vitro or in vivo, and previously described DAPK1-NMDAR disrupting peptides act by blocking the NMDA receptor.

Innovative approaches were used to identify the specific pharmacological properties of heterodimeric metabotropic glutamate receptors composed of mGlu2 and mGlu4 subunits, and reveal their existence in a neuronal cell line and in perforant path terminals.

Neurons in the hypothalamus that promote satiety manifest plasticity of their response to the excitatory transmitter, glutamate, by re-organizing the composition of a specific glutamare receptor.

The development of diet-dependent obesity results in the deterioration of calcium homeostasis in pro-opiomelanocortin-expressing neurons and impaired function of the same neurons.