A novel virtual reality-based contextual fear conditioning paradigm for head-fixed mice that elicits robust freezing behavior and enables multiphoton imaging of neural circuits underlying learning, memory, and fear.
Subcellular sequestration of caspase near membrane-associated proteins enables its non-lethal activation, which modulates neuronal function and innate olfactory behavior in the adult Drosophila olfactory receptor neurons.
Advanced electron microscopy techniques have been applied to comprehensively describe the cellular details and ultrastructural characteristics of all sensilla within the external sensory system of Drosophila larvae.
A neurogenetic approach reveals the cellular division of labor between individual Drosophila larval dopaminergic neurons encoding an averive teaching signal, reflecting principles in the adult insect and vertebrate brain.
Haley N Mendoza-Romero, Jessica E Biddinger ... Richard Simerly
Hypothalamic microglia play an essential role in mediating changes to feeding circuitry caused by exposure to maternal HFD that may contribute to developmental programming of metabolic phenotype.
Individuals with a late circadian rhythm show the same deficits in motivational decision-making as those with neuropsychiatric symptoms, but only when tested in the morning.
A longitudinal, deep learning approach reveals challenges and opportunities in establishing brain age as an effective metric of aging, with particular consideration given to underrepresented populations in Asia.
