Larger dendritic diameter, increased conductance load at the soma, and differences in cable and ion channel properties enable faster signal propagation in human neocortical dendrites, preserving information processing speed.
Franziska Auer, Katherine Nardone ... David Schoppik
Purkinje cells influence postural control in developing zebrafish, revealing age-dependent cerebellar contributions to balance and establishing a powerful model for studying cerebellar control of postural maturation.
The distributed network of working memory, encompassing frontal, parietal, and sensory cortices, flexibly reconfigures under different tasks to adapt to varying control demands.
When navigating environments with changing rules, human brain circuits flexibly adapt how and where we retain information to help us achieve our immediate goals.
β-CTF of APP, not Aβ, induces synaptic loss in a cell-autonomous manner, revealing APP misregulation may contribute to the pathogenesis of Alzheimer's disease via an Aβ-independent mechanism.
Simply crushed zizyphi spinosi semen not only ameliorates Aβ, tau, and α-synuclein pathology in dementia model mice, but also rejuvenates brain function by suppressing cellular senescence in normal aged mice.
