Designer Receptors Exclusively Activated by Designer Drug (DREADD) expression in macaque brains peaks around 2 months after adeno-associated virus injection and remains stable for over a year before gradually declining.
Predicting key future moments requires ignoring most irrelevant time, and alpha and beta power modulations encode sequential temporal landmarks via a gain-control mechanism that suppresses these irrelevant periods.
Noelle L Koonce, Sarah E Emerson ... Daniel A Colón-Ramos
NeuroSC provides an open-source framework for comparative connectomics, integrating neuronal morphologies, contacts, and synapses across developmental stages and datasets.
A modified rabies-based circuit-mapping strategy combined with physiology, optogenetics, and behavior identifies asymmetric corticostriatal subcircuits that exert distinct control over actions.
There is significant information about continuous 3D tongue direction contained in the primate orofacial sensorimotor cortex during untrained tasks, and alterations to tongue kinematics and directional tuning with temporarily induced sensory loss.
A novel connectomics approach reveals synaptic connectivity differences between narrowly and broadly tuned olfactory glomeruli in Drosophila melanogaster, providing new insights into glomerular circuitry and its putative computational roles.
Nare Karagulyan, Maja Überegger ... Christine Bandtlow
Loss of RTN4RL2 disrupts synapse formation and function between inner hair cells and spiral ganglion neurons, leading to elevated auditory thresholds and highlighting its critical role in hearing.
