There is no discernible effect of an additional year of education from a policy change on long-term structural neuroimaging measures in a large aging sample (UK Biobank).
Homotypic olfactory receptor neurons in Drosophila, including CO2-sensing neurons with distinctive sheet-like dendrites, exhibit unexpected morphological diversity that may underlie functional adaptability.
Aurore Thomazeau, Sabine Rannio ... Per Jesper Sjöström
Neocortical timing-dependent LTD relies on non-ionotropic presynaptic NMDA receptor signaling via JNK2, challenging the textbook view that NMDA receptors are ionotropic coincidence detectors in Hebbian plasticity.
Michelle Jin, Simon O Ogundare ... Christine Ann Denny
A new scalable workflow for analyzing multiple ensemble datasets incorporates SMARTTR, an R package supporting network analysis, visualization, and the import of external datasets.
Johanna Ganssauge, Sophie Hawkins ... Akshay Bhinge
A novel human iPSC-derived model induces mislocalization of endogenous TDP-43 without mutations or stress, recapitulating key ALS features including deficits in neuronal loss and morphology, splicing errors, and microRNA dysregulation.
The BRAIN Circuits Program of the NIH BRAIN Initiative has impacted how fundamental discovery in integrative systems neuroscience is investigated, commensurate with the complexity to address neurobehavioral and neurological dysfunctions.
Formation of specialized ribbon synapses in sensory hair cells involves dynamic precursor movement, microtubule-guided transport, and precursor fusion, culminating in synapse assembly essential for hearing and balance.
ABBA ensures proper cortical development by regulating radial glial division through RhoA activity at the cleavage furrow, and its mutation results in developmental abnormalities linked to microcephaly.
