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    1. Neuroscience

    Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis

    Jian Dong, Miao Chen ... Matthijs Verhage
    Rab10 deficiency unexpectedly inhibits neuropeptide secretion through two distinct effects on the endoplasmic reticulum (ER), disrupting ER-regulated intracellular Ca²⁺ dynamics and impairing protein synthesis.
    1. Neuroscience

    The NIH BRAIN Initiative’s Impacts in Systems and Computational Neuroscience, 2014-2023

    Farah Bader, Clayton Bingham ... On behalf of the NIH BRAIN Initiative Integrative and Quantitative Neuroscience Team
    Not revised
    Reviewed Preprint v1
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    • Incomplete
    1. Neuroscience

    Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive behavior

    Brian C Ruyle, Sarah Masud ... Jose A Morón
    The peripherally restricted opioid receptor antagonist naloxone methiodide reverses fentanyl-induced respiratory depression without causing aversive behaviors that are observed after naloxone.
    1. Neuroscience

    Infralimbic parvalbumin neural activity facilitates cued threat avoidance

    Yi-Yun Ho, Qiuwei Yang ... Melissa R Warden
    Infralimbic inhibitory parvalbumin neurons play a counterintuitive role in supporting flexible behavior in the face of threat.
    1. Neuroscience

    Ethograms predict visual fear conditioning status in rats

    David C Williams, Amanda Chu ... Michael A McDannald
    A more complete, bidirectional relationship between fear conditioning and behavior is established when many behaviors are examined, as opposed to single behavior such as freezing.
    1. Neuroscience

    In vivo autofluorescence lifetime imaging of the Drosophila brain captures metabolic shifts associated with memory formation

    Philémon Roussel, Mingyi Zhou ... Auguste Genovesio
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Neuroscience

    Anterior cingulate cortex in complex associative learning: monitoring action state and action content

    Wenqiang Huang, Arron F Hall ... Dong V Wang
    Not revised
    Reviewed Preprint v1
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    • Incomplete
    1. Neuroscience

    Mapping Visual Contrast Sensitivity and Vision Loss Across the Visual Field with Model-Based fMRI

    Hugo T Chow-Wing-Bom, Matteo Lisi ... Tessa M Dekker
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Ecology
    2. Neuroscience

    Interdependence between SEB-3 receptor and NLP-49 peptides shifts across predator-induced defensive behavioral modes in Caenorhabditis elegans

    Kathleen T Quach, Gillian A Hughes, Sreekanth H Chalasani
    As Caenorhabditis elegans shifts from reactive to increasingly proactive defensive strategies, nuanced changes in interaction between SEB-3 receptor and NLP-49 peptides regulate the transitions between defensive behaviors.
    1. Neuroscience

    Respiratory and cardiac interoceptive sensitivity in the first two years of life

    Markus R Tünte, Stefanie Hoehl ... Ezgi Kayhan
    Infants are sensitive to their own respiration and heartbeat already in the first two years of life.
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