Browse our latest Structural Biology and Molecular Biophysics articles

GluK1-1 splice variant alters the gating properties of kainate receptors, providing crucial insights into receptor modulation by auxiliary proteins and advancing the understanding of synaptic transmission.

By harnessing antibody fragments conjugated to small gold nanoparticles together with high pressure freezing, FIB/SEM milling and cryo-electron tomography, AMPA receptors were identified from mouse brain tissue.

Proteins in the Transmembrane Channel-Scramblase (TCS) superfamily share an evolutionarily conserved ability to permeate ions and phospholipids, challenging distinctions between ion channels and lipid scramblases.

The cooling agent pocket in TRPM8 is conserved in a subset of other TRPM channels and the cooling agent icilin can regulate opening of TRPM4 channels in response to calcium and voltage.

Polyunsaturated fatty acids activate IKs channels by stabilizing a conductive state of the selectivity filter.

ATP prevents condensation of aggregation-prone intrinsically disordered protein by modulating its conformation.

SeqDYN, a sequence-based method, accurately predicts the residue-specific transverse relaxation rates of intrinsically disordered proteins.

Design and characterization of allosteric mutations that recapitulate TRPML1 gating and structural insights into PI(4,5)P₂ and sphingomyelin inhibition of TRPML1.