Browse our latest Structural Biology and Molecular Biophysics articles

Jyvaskylavirus, the northernmost isolate of the Marseilleviridae family, shows that giant viruses are also part of the boreal Finnish environment and brings structural information with relevance for understanding other viruses.

Computational modeling and in vitro experiments identify a unique conformational state in amyloidogenic light chains, providing a structural basis for amyloidosis and a precise target for drug design.

A combination of polymer physics theories consistently rationalizes comprehensive experimental effects of salt, ATP, phosphorylation, and sequence charge and arginine/lysine patterns on the reentrant phase behaviors of intrinsically disordered proteins.

Multi-level molecular modeling reveals how PROTAC-induced protein structural dynamics of degradation machinery complexes promote ubiquitination processes.

Nature has inspired the design of improved inhibitors for cancer-causing proteins.

Computational and experimental evidence shows that the reaction catalyzed by adenylate kinase operates through a broad transition-state ensemble (TSE), utilizing protein conformational diversity to reduce activation entropy.

The well-studied Kv1.2 potassium ion channel is observed in a variety of states and conditions, to understand mechanisms of ion permeation, gating and block.