Browse our latest Structural Biology and Molecular Biophysics articles

Cryo-EM structures of HsNCX1 in complex with either phosphatidylinositol 4,5-bisphosphate (a physiological activator) or SEA0400 (a pharmacological inhibitor) provide mechanistic insights into the cellular regulation and pharmacology of NCX proteins.

Drugs are identified that unmask molecular origins of certain neuronal potassium currents, enabling functional analysis of previously indistinguishable potassium channel subtypes.

New protein-protein docking algorithm combining deep learning (AlphaFold2) and physics (Rosetta and enhanced sampling) achieves high success rates.

AACDB provides a comprehensive, manually curated antigen-antibody interface dataset with rich metadata, interaction annotations, and therapeutic target annotations to advance antibody drug development.

Solution biophysics defines the influence of local dynamics and allosteric regulation on guide RNA binding affinity and DNA cleavage specificity in a thermophilic Cas9 from Geobacillus stearothermophilus.

Structural and biochemical analyses suggest the association of homotrimeric CesAs of different isoforms into cellulose biosynthesis complexes via their class-specific regions.

Lysophospholipids directly and reversibly activate pannexin channels, triggering the release of signaling molecules critical for inflammation.

Multiple walker supervised molecular dynamics simulations deliver insights on glucagon-like peptide 1 receptor activation, G_s protein binding, and guanosine diphosphate release from the G_sα subunit using an adaptive sampling approach.