Browse our latest Structural Biology and Molecular Biophysics articles

An epilepsy-associated potassium channel variant causes neuron-type-dependent alterations in ionic currents, neuronal excitability, and network connectivity.

LptC regulates the LPS entry gate in LptB₂FG, likely through a dynamic behavior of its transmembrane helix, while the β-jellyroll domains are tethered in the periplasm.

Structural dynamic insights revealed the mechanisms of PC1 activation by stalk-derived peptide agonists which can form a foundation for development of PC1 as a therapeutic target for ADPKD treatment.

The cryo-EM structure of the CG6765 BTB domain and solution scattering experiments revealed a unique three-dimer hexameric assembly for the arthropod Tramtrack group BTB domains.

Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.

PPI-hotspot^ID, trained using an automated machine-learning framework, AutoGluon, on the largest PPI-hot spot dataset to date, detects hot spots beyond protein–protein interfaces, uncovering druggable interactions to aid design of PPI-modulating therapeutics.

Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

Deep mutational scanning reveals interactions in the MET kinase domain that are critical for regulation and cancer-related signaling.

The phenotype of mutant potassium channels described here allows the mechanistic dissection of the complex process of potassium channel gating in the pathology-relevant KCNH family.