Browse our latest Structural Biology and Molecular Biophysics articles

HS-AFM and Principal Component Analysis provide experimental evidence to substantiate the 'proof of principle' regarding the flexible helical twists of actin filaments that regulate the functions of actin-binding proteins.

A comprehensive exploration of α-synuclein (αS) aggregation dynamics from both macroscopic and microscopic perspectives uncovers the intricate mechanisms underlying crowder and salt-induced intensification of αS self-aggregation.

P-Rex1 adopts an inactive, compact conformation that is stabilized by an abundant intracellular molecule and undergoes dynamic changes to extend upon encountering signaling phospholipids in membranes.

Many of the synergistic interactions between mutations are modified in the context of unstable proteins in a manner that depends on how the variants promote misfolding in the cell.

The manner in which protons control the conformational behaviour of mammalian peptide transporters is revealed through state-of-the-art molecular dynamics simulations supported by cell-based assays.

Our latest Special Issue brings together research on the allosteric regulation of kinase activity.

The articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation.