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Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.

Ligand-driven enhancer activation selectively boosts target gene expression while indirectly repressing neighboring non-target genes, revealing dynamic and competitive regulation during early transcriptional responses.

Genes associated with male reproductive biology appear to be under relaxed selective constraint in a primate species with low sperm competition.

DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.

Systematic characterization of terminating ribosomes uncovers sequence features influencing ribosome dynamics at stop codons with direct implications in 3' UTR translation.

Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full maturity.