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Page 5 of 1,818
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

    Pien Margien van Paassen, Alexander O Pasternak ... Godelieve J de Bree
    In individuals who started antiretroviral therapy during acute HIV infection, the proliferative capacity of HIV-specific CD8+ T-cells at 24 weeks of therapy predicted the subsequent reduction in the viral reservoir.
    1. Cancer Biology
    2. Physics of Living Systems

    Robust assessment of asymmetric division in colon cancer cells

    Domenico Caudo, Chiara Giannattasio ... Mattia Miotto
    Combining statistical modeling with flow cytometry enables reliable, high-throughput quantification of division asymmetry in live cells, revealing how partitioning noise may shape tumor cell heterogeneity.
    1. Cell Biology

    The IBEX knowledge-base a community resource enabling adoption and development of immunofluorescence imaging methods

    Ziv Yaniv, Ifeanyichukwu U Anidi ... Andrea J Radtke
    A dynamic, community-driven knowledge repository reduces research costs and accelerates scientific discovery by sharing validated reagent data, negative results, and protocols while rewarding contributors through formal authorship recognition.
    1. Computational and Systems Biology
    2. Neuroscience

    Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

    Aske Ejdrup, Jakob Kisbye Dreyer ... Ulrik Gether
    A computational model of the striatal dopamine system predicts transporter expression and organisation as key determinants of regional striatal dopamine dynamics and distinct signal decoding by D1 and D2 receptors.
    1. Cell Biology

    A single-cell atlas of the testicular interstitium defines Leydig progenitor networks sustaining Leydig cell homeostasis across the lifespan

    Xiaojia Huang, Kai Xia ... Wei Zhao
    Single-cell transcriptomic analysis of the murine testicular interstitium across the lifespan reveals Cd34+/Sox4+ mesenchymal cells as Leydig progenitors, whose aging-associated decline in glutathione and Sox4-regulated regenerative capacity inform potential therapeutic strategies for age-related testicular dysfunction.
    1. Neuroscience

    Domain-adaptive matching bridges synthetic and in vivo neural dynamics for neural circuit connectivity inference

    Kaiwen Sheng, Shanghang Zhang ... Kai Du
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    Benchmarking of signaling networks generated by large language models

    Jeevan Tewari, Benjamin W Dahl, Jeffrey J Saucerman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Subregional activity in the dentate gyrus is amplified during elevated cognitive demands

    Charlotte CM Castillon, Shintaro Otsuka ... Anis Contractor
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Improved inference of latent neural states from calcium imaging data

    Stephen Keeley, David Zoltowski ... Jonathan Pillow
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

    Dirk EM Geurts, Hanneke EM den Ouden ... Roshan Cools
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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