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    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology

    Profiling of terminating ribosomes reveals translational control at stop codons

    Longfei Jia, Yuanhui Mao ... Shu-Bing Qian
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Compelling
    • Incomplete
    1. Physics of Living Systems

    Quantifying intracellular mechanosensitive response upon spatially defined mechano-chemical triggering

    Elaheh Zare-Eelanjegh, Renard TM Lewis ... Tomaso Zambelli
    Cellular mechanotransmission depends on nuclear lamina composition, where A-type and B-type lamins define distinct nuclear mechanical responses, and microtubules dynamically buffer intracellular tension.
    1. Immunology and Inflammation

    Tracheal terminal cells of Drosophila are immune privileged to maintain their Foxo-dependent structural plasticity

    Judith Bossen, Larissa Fritz ... Thomas Roeder
    Terminal tracheal cells in Drosophila evade innate immune activation, revealing a fundamental trade-off in which suppression of canonical immune signaling preserves Foxo-dependent plasticity and sustains respiratory function.
    1. Cell Biology
    2. Neuroscience

    Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release

    Javier Emperador-Melero, Steven J Del Signore ... Avital A Rodal
    Presynaptic endocytic machinery is constitutively deployed to periactive zones, indicating independent assembly pathways for the exo- and endocytic machineries of nerve terminals.
    1. Neuroscience

    Long Wake/Short Sleep Bouts and Hyperactivity with Advanced Age in a Mouse Model of Early Onset Alzheimer’s Disease

    Ryan K Tisdale, Yu Sun ... Thomas S Kilduff
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Conformational Variability of HIV-1 Env Trimer and Viral Vulnerability

    Yiwei Cao, Wonpil Im
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Theta-Beta Ratio in Attention Deficit Hyperactivity Disorder: A Multiverse Analysis

    Dawid Strzelczyk, Andrea Vetsch, Nicolas Langer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Exceptional
    1. Neuroscience
    2. Computational and Systems Biology

    SqueakPose Studio: An end-to-end platform for pose estimation and real-time edge-AI deployment

    David L Haggerty, Caleb B Darden, David M Lovinger
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Atomistic simulations reveal sub-µs contact dynamics in MUT-16 condensates

    Kumar Gaurav, Lucia Baltz ... Lukas S Stelzl
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
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