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Page 5 of 1,870
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The adaptive landscapes of three global Escherichia coli transcriptional regulators

    Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner
    Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping which outcomes prevail.
    1. Computational and Systems Biology
    2. Developmental Biology

    Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation

    Morena Raiola, Miquel Sendra Sendra ... Miguel Torres
    A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.
    1. Developmental Biology

    Single-cell characterization of anterior segment development in the mouse reveals the cell types, pathways, and signals driving formation of the trabecular meshwork and Schlemm’s canal

    Revathi Balasubramanian, Nicholas Tolman ... Simon WM John
    High-resolution single-cell transcriptomics reveals the molecular programs and signaling networks driving Schlemm's canal and trabecular meshwork development, establishing a foundation for understanding glaucoma pathogenesis.
    1. Microbiology and Infectious Disease

    Reactive oxygen detoxification contributes to Mycobacterium abscessus antibiotic survival

    Nicholas A Bates, Ronald Rodriguez ... Bennett H Penn
    Antibiotics that inhibit translation cause a burst in reactive oxygen species, and these must be detoxified by factors such as KatG for cells to survive.
    1. Developmental Biology

    A genetic screen reveals dosage-sensitive effects of ASD genes and identifies domino as a regulator of synaptic and behavioral phenotypes

    Ellen Stirtz, Zachary B Madaj ... Adelheid Lempradl
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Medicine

    Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

    Fangluo Chen, Muzna Saqib ... G William Wong
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Germline-somatic residue synergy reshapes antibody encounter-state pathways to enhance HIV-1 recognition

    Sangita Kachhap, Yishak Bililign ... Rory Henderson
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Structural basis for site-specific histone H3 acetylation-dependent regulation of RNAPII transcription through nucleosomes

    Takumi Oishi, Suguru Hatazawa ... Hitoshi Kurumizaka
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    A stable cryogenic fluorescence microscope for correlative super-resolution light and electron microscopy

    Soheil Mojiri, Joseph M Dobbs ... Jonas Ries
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    1. Neuroscience

    Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex

    Brandon Williams, Riya Dahal ... John A White
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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