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Page 5 of 1,870
    1. Neuroscience

    PKMζ-PKCι/λ double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    Double-knockout of PKMζ and the other atypical PKC, PKCι/λ, reveals that, without PKMζ for maintenance, PKCι/λ becomes persistently active to sustain hippocampal late-LTP and long-term memory.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Distinct prokaryotic gut microbiome and proviral-immune axes of pathophysiology in Sickle Cell Disease

    Zachary N Flamholz, Jennifer De Los Santos ... Libusha Kelly
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Opto-MDMi: a dual-lock optogenetic system for robust activation of endogenous p53

    Tatsuki Tsuruoka, Takashi Sumikama ... Kazuhiro Aoki
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Developmental Biology

    Comparative single-cell transcriptomic roadmap of mammalian fetal ovarian development

    Yifei Fang, Shiyao Han ... Jingyue Ellie Duan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

    Surbhi Verma, Shweta Thakur ... Dhiraj Kumar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Unexpected plasticity in the life cycle of Trypanosoma brucei

    Carina Praisler, Jaime N Lisack ... Markus Engstler
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

    Qian Wang, Liping Li ... Chuo Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    The cistrome response to hypoxia in human umbilical vein endothelial cells

    Ayush Singh, Viktor Pastukh ... Hank W Bass
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    The openretina Project: Collaborative Retina Modelling Across Datasets and Species

    Federico D’Agostino, Thomas Zenkel ... Matthias Bethge
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Developmental Biology

    Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation

    Morena Raiola, Miquel Sendra Sendra ... Miguel Torres
    A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.
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