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    1. Neuroscience

    Locus coeruleus modulation of prefrontal dynamics during attentional switching in mice

    Marco Nigro, Lucas Silva Tortorelli ... Hongdian Yang
    Inhibiting locus coeruleus input to the medial prefrontal cortex in mice impaired task performance, affected the tuning of single cortical neurons and disrupted population dynamics and encoding capacity during attentional switching.
    1. Neuroscience

    A context-free model of savings in motor learning

    Mahdiyar Shahbazi, Olivier Codol ... Paul L Gribble
    Recurrent neural network models trained on a novel motor skill exhibit a persistent shift in preparatory activity that enables faster relearning, without cognitive or contextual cues.
    1. Immunology and Inflammation
    2. Neuroscience

    Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability

    Simone Carneiro-Nascimento, Chao Wei ... Dan Levy
    Intravital microscopy of meningeal macrophage Ca²⁺ dynamics reveals previously unknown population heterogeneity, vasomotion-coupled activity, and diverse responses during steady state and neuroinflammatory conditions, offering relevant insights into brain immune regulation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell

    David Jones, Hugo Belda ... Moritz Treeck
    Fever, often seen as protective, accelerates protein export to surfaces of malaria-infected RBCs, increasing adhesion linked to disease severity.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Convincing
    1. Neuroscience

    Characterisation of cold-selective lamina I spinal projection neurons in the mouse

    Aimi N Razlan, Wenhui Ma ... Junichi Hachisuka
    Lamina I projection neurons that respond selectively to skin cooling receive monosynaptic input from Trpm8-expressing primary afferents and innervate brain regions involved in perception of cold and cold defence mechanisms.
    1. Cell Biology

    Regulation of sphingolipid synthesis by the C2H2 zinc finger transcription factor Com2 through ubiquitin-proteasome mediated degradation pathway

    Kosei Matsumoto, Ayane Nagai ... Mitsuaki Tabuchi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Solid
    1. Developmental Biology
    2. Computational and Systems Biology

    Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the Drosophila embryo

    Hadel Al Asafen, Natalie M Clark ... Gregory T Reeves
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Evolutionary Biology

    Evolutionary dynamics of insect odorant receptors reveal ecological tuning shaping olfactory perception

    Tianmin Zhang, Xuanxiao Yang ... Huimeng Lu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience
    2. Physics of Living Systems

    Nicotine-driven hyperactivation of larval locomotion

    Stephanie Dancausse, Jocelyn Robles ... Mason Klein
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach

    Nisheeth Agarwal, Himanshu Gogoi ... Bappaditya Dey
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete