Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.
Rochelle M Shih, Yasuhiro Arimura ... Hironori Funabiki
DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.
Systematic characterization of terminating ribosomes uncovers sequence features influencing ribosome dynamics at stop codons with direct implications in 3' UTR translation.
Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full maturity.