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    1. Computational and Systems Biology

    Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability using UniDesign

    Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
    A fully computationally designed SaCas9 variant expands PAM recognition to NNNRRT, achieving up to 116-fold higher editing at noncanonical sites while matching the performance of experimentally evolved variants.
    1. Neuroscience

    Development of Auditory and Spontaneous Movement Responses to Music over the First Postnatal Year

    Trinh Nguyen, Félix Bigand ... Giacomo Novembre
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation

    Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency

    Eliezer Heller, Lucas dos Santos Dias, Michail S Lionakis
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Calibrated analysis framework for nanopore direct RNA sequencing uncovers cell-specific m6A stoichiometry at conserved sites

    Denise Ohnezeit, Elene Loliashvili ... Angus C Wilson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Cancer Biology

    Tumors mimic the niche to inhibit neighboring stem cell differentiation

    Yang Zhang, Yuejia Wang ... Shaowei Zhao
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
    • Incomplete
    1. Developmental Biology

    Functional definition of the Drosophila airway progenitor field through overlapping compensatory regulators

    Ryo Matsuda, Chie Hosono ... Christos Samakovlis
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis

    Yuqian Shen, Ziyang Wang ... Dong Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression

    Jacob S Dearborn, Luke Frankiw ... Devdoot Majumdar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bicarbonate receptor GPR30

    Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Cell Biology
    2. Computational and Systems Biology

    Geometry shapes cytoplasmic Cdk1 waves that drive cortical dynamics

    Daniel Cebrián-Lacasa, Marcin Leda ... Lendert Gelens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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