Browse our latest research

Page 5 of 1,866
    1. Neuroscience

    Electroconvulsive stimulation drives cortical spreading depression dependent immediate early gene expression in mice

    Hugo J Ladret, Leonardo Lupori ... Georg B Keller
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Medicine
    2. Neuroscience

    Synthetic torpor in the rat protects the heart from ischaemia-reperfusion injury

    Megan Elley, Ludovico Taddei ... Michael Ambler
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Neuroscience

    Stable excitatory-inhibitory synapse balance despite dynamic turnover

    Krassimira A Garbett, James P Allen ... Richard C Sando
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Disentangling cephalopod chromatophores motor units with computer vision

    Mathieu DM Renard, Johann Ukrow ... Gilles Laurent
    The spatial organization of chromatophore-muscle innervation by motoneurons enables the generation of chromatophore-shaped noise, virtual or composite chromatophores, and shape elements such as lines or small blobs.
    1. Structural Biology and Molecular Biophysics

    Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

    Arpa Hudait, Ryan C Burdick ... Gregory A Voth
    Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
    1. Genetics and Genomics

    Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity

    Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
    Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.
    1. Neuroscience

    Medial prefrontal cortex encodes but is not required to generate goal-directed actions under threat

    Muhammad S Sajid, Ji Zhou, Manuel A Castro-Alamancos
    Medial prefrontal cortex activity is not required for learning or execution of adaptive avoidance behavior, despite encoding select task features.
    1. Immunology and Inflammation

    Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

    Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
    A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.
    1. Cell Biology

    Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

    Qian Lyu, Qingchao Li ... Huijie Zhao
    Deficiency in any of the interdependent C2a proteins (CCDC108, MYCBPAP, and CFAP70) collapses this central pair microtubule-associated projection, disrupting vertebrate ciliary movement, and causing primary ciliary dyskinesia phenotypes in mice.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions

    Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin
    Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.