Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.
Two families of ubiquitin ligases secreted by the intracellular pathogen Legionella pneumophila utilize distinct chemistries to form a stable, ubiquitin-rich structure around the vacuole, which is subsequently disassembled as infection progresses.
