Browse our latest research

Page 5 of 1,817
    1. Developmental Biology

    Permissive and instructive Hox codes govern limb positioning

    Yajun Wang, Maik Hintze ... Ruijin Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators

    Charles S Lazimi, Austin E Stis ... Edward A Phelps
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression

    The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

    Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Genetics and Genomics

    Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

    Nicholas Tolman, Taibo Li ... Simon WM John
    Single-cell transcriptomics identifies three discrete mouse trabecular meshwork subtypes and demonstrates that an Lmx1b glaucoma mutation drives mitochondrial dysfunction and elevated intraocular pressure, which is lessened by vitamin B3 supplementation.
    1. Stem Cells and Regenerative Medicine

    Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of osteoarthritis

    Nedaa Al-Jezani, Asmaa Affan ... Roman J Krawetz
    CD47Hi synovial mesenchymal stem cells are identified as a functionally distinct sub-population that regenerates articular cartilage and reduces osteoarthritis severity in a preclinical joint injury model.
    1. Neuroscience

    Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)

    Michael W Reimann, Sirio Bolaños-Puchet ... Srikanth Ramaswamy
    A morphologically detailed model of brain region anatomy serves as the foundation for biophysically detailed simulations and provides insights into local and inter-regional connectivity.
    1. Neuroscience

    Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation)

    James B Isbister, Andras Ecker ... Michael W Reimann
    A general and open multiscale cortical model is presented which can be used by the community to study neural coding, spike sorting, plasticity, optogenetic and extracellular stimulation, local field potential, and electroencephalography.
    1. Chromosomes and Gene Expression

    ATAD2 mediates chromatin-bound histone chaperone turnover

    Ariadni Liakopoulou, Fayçal Boussouar ... Saadi Khochbin
    ATAD2 orchestrates histone turnover during spermatogenesis, regulating H3.3 deposition, chromatin condensation, and genome packaging to ensure proper sperm genome organization and transcriptional control.
    1. Cell Biology

    Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

    Yunpo Zhao, Jianli Duan ... Zhe Han
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
Newer articles Older articles