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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
    Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.
    1. Cell Biology
    2. Genetics and Genomics

    Non-visual light modulates behavioral memory and gene expression in Caenorhabditis elegans

    Zhijian Ji, Bingying Wang ... Dengke K Ma
    Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenetic-like gene control without photoreceptors.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Neuroscience

    Sex–specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain

    Anisa Gumerova, Georgii Pevnev ... Vitaly Ryu
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Insights into substrate binding and utilization by hyaluronan synthase

    Zachery Stephens, Julia Karasinska, Jochen Zimmer
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology

    Interrogating the structure and function of the human voltage-gated proton channel (hHv1) with a fluorescent noncanonical amino acid

    Emerson M Carmona, William N Zagotta, Sharona E Gordon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Ventral Hippocampal Temporoammonic and Schaffer Collateral Pathways Differentially Control Fear- and Anxiety-Related Behaviors

    Maltesh Kambali, Muxiao Wang ... Uwe Rudolph
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    A Conserved Mycobacterial Nucleomodulin Hijacks the Host COMPASS Complex to Reprogram Pro-Inflammatory Transcription and Promote Intracellular Survival

    Liu Chen, Baojie Duan ... Aizhen Guo
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Medicine
    2. Computational and Systems Biology

    Global molecular landscape of early MASLD progression in obesity

    Qing Zhao, William De Nardo ... Philipp Kaldis
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Microbiology and Infectious Disease

    Mycobacterial Metallophosphatase MmpE acts as a Nucleomodulin to Regulate Host Gene Expression and Promote Intracellular Survival

    Liu Chen, Baojie Duan ... Aizhen Guo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Structure of the human CTF18−RFC clamp loader bound to PCNA

    Giuseppina R Briola, Mohammad Tehseen ... Alfredo De Biasio
    Human CTF18–RFC employs a unique structural stabilization mechanism to optimize PCNA loading and stimulate DNA synthesis by the leading-strand polymerase.
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