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Page 5 of 1,861
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies

    Yi Lin, Benjamin Liou ... Ying Sun
    Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and therapeutic strategies in human context.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent ciliary signaling.
    1. Neuroscience

    Dopamine ramps as a normative consequence of dual-process control

    Luke Priestley, Thomas Akam
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys

    Kathryn Branam, Joshua I Gold, Long Ding
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Developmental Biology
    2. Neuroscience

    Transcriptional profiling of extraocular motor neurons reveals sim1a as a candidate strabismus-related gene

    Emily Gershowitz, Kyla Rose Hamling ... David Schoppik
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Reduction of complex dynamic touch information to a single stable perceptual feature

    Naghmeh Zamini, Benjamin Stephens-Fripp ... Jess Hartcher-O’Brien
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection

    Christopher Peterson, Joshua Miller ... Vitaly V Ganusov
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    Identification of nuclear pore proteins at plasmodesmata: potential role in intercellular transport?

    T Moritz Schladt, Manuel Miras ... Wolf B Frommer
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    1. Microbiology and Infectious Disease
    2. Evolutionary Biology

    Essential function reflected in the phylodynamics of a multigene family – the pir genes of malaria parasites

    Andrew P Jackson, Deirdre A Cunningham ... Christiaan van Ooij
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Decoding spine nanostructure in cultured neurons derived from mouse models of mental disorder reveals a schizophrenia-linked role for Ecrg4

    Yutaro Kashiwagi, Qingrui Liu ... Shigeo Okabe
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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