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    1. Neuroscience

    Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)

    Michael W Reimann, Sirio Bolaños-Puchet ... Srikanth Ramaswamy
    A morphologically detailed model of brain region anatomy serves as the foundation for biophysically detailed simulations and provides insights into local and inter-regional connectivity.
    1. Cell Biology

    Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

    Yunpo Zhao, Jianli Duan ... Zhe Han
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Genetics and Genomics

    Reproducibility of Scientific Claims in Drosophila Immunity: A Retrospective Analysis of 400 Publications

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    • Incomplete
    1. Developmental Biology

    Progressive mural cell deficiencies across the lifespan in a foxf2 model of Cerebral Small Vessel Disease

    Merry Faye E Graff, Emma EM Heeg ... Sarah J Childs
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

    Ravi Kumar, Simon Couly ... Ashish Lal
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Genetics and Genomics

    A retrospective analysis of 400 publications reveals patterns of irreproducibility across an entire life sciences research field

    Joseph Lemaitre, Désirée Popelka ... Bruno Lemaitre
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cancer Biology
    2. Cell Biology

    GMCL1 controls 53BP1 stability and modulates taxane sensitivity

    Yuki Kito, Tania J González-Robles ... Michele Pagano
    GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.
    1. Structural Biology and Molecular Biophysics

    A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

    Ivana Petrovic, Samit Desai ... Stephan Grzesiek
    Formation and stability of endocytic receptor-arrestin complexes during clathrin-mediated endocytosis are governed by phosphorylation-dependent arrestin-AP2 interactions.
    1. Computational and Systems Biology
    2. Neuroscience

    Predicting human decision-making across task conditions via individuality transfer

    Hiroshi Higashi
    Encoding individual behavioral traits into a low-dimensional latent representation enables the accurate prediction of decision-making patterns across distinct task conditions.
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