Browse our latest research

Page 5 of 1,856
    1. Microbiology and Infectious Disease

    Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis

    Helge Feddersen, Charlotte Dyckmans, Marc Bramkamp
    Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min system dynamics.
    1. Chromosomes and Gene Expression

    Uncoupling the TFIIH Core and Kinase Modules leads to misregulated RNA polymerase II CTD Serine 5 phosphorylation

    Gabriela Giordano, Robin Buratowski ... Stephen Buratowski
    The TFIIH subunit Tfb3/MAT1 can be split into two parts to uncouple the TFIIH kinase and DNA translocase modules, resulting in unfocused C-terminal domain phosphorylation.
    1. Neuroscience

    A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head

    Steven A Calle-Schuler, Alexis Santana-Cruz ... Andrew M Seeds
    A synaptic-resolution map reveals how spatially organized touch pathways in the fly brain shape aimed head grooming through parallel excitatory circuits and inhibitory control.
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Muscarinic cholinergic signaling links neural activity to organism‑wide transcriptional and proteostatic responses that protect against chronic oxidative stress.
    1. Developmental Biology
    2. Computational and Systems Biology

    Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids

    Catherine G Triandafillou, Pranav Sompalle ... Arjun Raj
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Medicine

    Navigating the Path: Advice to Physician-Scientists on Choosing a Clinical Specialty

    Talia H Swartz, José E Cavazos ... Christopher S Williams
    Revised
    Reviewed Preprint v2
    Updated
    1. Neuroscience

    α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors

    Rixu Cong, Huiran Li ... Chen Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Developmental Biology

    The NTR/prodrug revolution: Tools for controlling cell loss and regeneration

    Gha-Hyun J Kim, Michael Parsons
    Improved nitroreductase variants, optimized prodrugs, and careful experimental design enable scalable, precise cell ablation across model systems for disease modeling, regeneration studies, and high-throughput discovery.
    1. Neuroscience

    Growth in early infancy drives optimal brain functional connectivity which predicts cognitive flexibility in later childhood

    Chiara Bulgarelli, Anna Blasi ... The BRIGHT Study Team
    In Gambian infants, positive growth from 0 to 5 months of age predicted more mature brain networks, which in turn predicted cognitive outcomes at 3-5 years.
    1. Genetics and Genomics

    Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity

    Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid