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Page 5 of 1,848
Computational and Systems Biology
Fully computational design of PAM-relaxed
Staphylococcus aureus
Cas9 with expanded targeting capability using UniDesign
Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
A fully computationally designed SaCas9 variant expands PAM recognition to NNNRRT, achieving up to 116-fold higher editing at noncanonical sites while matching the performance of experimentally evolved variants.
Neuroscience
Development of Auditory and Spontaneous Movement Responses to Music over the First Postnatal Year
Trinh Nguyen, Félix Bigand ... Giacomo Novembre
Immunology and Inflammation
Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency
Eliezer Heller, Lucas dos Santos Dias, Michail S Lionakis
Chromosomes and Gene Expression
Computational and Systems Biology
Calibrated analysis framework for nanopore direct RNA sequencing uncovers cell-specific m
6
A stoichiometry at conserved sites
Denise Ohnezeit, Elene Loliashvili ... Angus C Wilson
Developmental Biology
Cancer Biology
Tumors mimic the niche to inhibit neighboring stem cell differentiation
Yang Zhang, Yuejia Wang ... Shaowei Zhao
Developmental Biology
Functional definition of the
Drosophila
airway progenitor field through overlapping compensatory regulators
Ryo Matsuda, Chie Hosono ... Christos Samakovlis
Developmental Biology
HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis
Yuqian Shen, Ziyang Wang ... Dong Liu
Chromosomes and Gene Expression
Immunology and Inflammation
Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression
Jacob S Dearborn, Luke Frankiw ... Devdoot Majumdar
Structural Biology and Molecular Biophysics
Cryo-EM structure of the bicarbonate receptor GPR30
Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki
Cell Biology
Computational and Systems Biology
Geometry shapes cytoplasmic Cdk1 waves that drive cortical dynamics
Daniel Cebrián-Lacasa, Marcin Leda ... Lendert Gelens
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