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    1. Cell Biology
    2. Computational and Systems Biology

    Geometry shapes cytoplasmic Cdk1 waves that drive cortical dynamics

    Daniel Cebrián-Lacasa, Marcin Leda ... Lendert Gelens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Defining the Antigenic Topology and Prospective Binding Breadth of Vaccination-induced SARS-CoV-2 Neutralizing Antibodies

    Deepika Jaiswal, Clara G Altomare ... Goran Bajic
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    A stress-responsive morphogenetic program of the uterine epithelium safeguards the establishment of early pregnancy

    Chihiro Ishizawa, Shizu Aikawa ... Yasushi Hirota
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Purified Zymogens Reveal Mechanisms of Snake Venom Metalloproteinase Auto-Activation

    Sophie Hall, Iara Aimê Cardoso ... Christiane Schaffitzel
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Immunology and Inflammation

    Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency

    Eliezer Heller, Lucas dos Santos Dias, Michail S Lionakis
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Plant Biology

    Herbivorous insects independently evolved salivary effectors to regulate plant immunity by destabilizing the malectin-LRR RLP NtRLP4

    Xin Wang, Jia-Bao Lu ... Hai-Jian Huang
    Salivary effectors from whiteflies and planthoppers have convergently evolved to undermine RLP4-mediated plant immunity.
    1. Physics of Living Systems

    Collective epithelial migration mediated by the unbinding of hexatic defects

    Dimitrios Krommydas, Livio N Carenza, Luca Giomi
    Theoretical and computational analyses demonstrate that cell intercalation within epithelial cell layers is analogous to the unbinding of topological defects in hexatic liquid crystals, offering a framework for calculating cellular forces and velocities during collective migration.
    1. Neuroscience

    Hugin-AstA circuitry is a novel central energy sensor that directly regulates sweet sensation in Drosophila and mouse

    Wusa Qin, Tingting Song ... Rui Huang
    A conserved neuropeptidergic circuit directly links internal glucose levels to sweet taste sensitivity, providing a central mechanism for coupling metabolic state to feeding behavior.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Human adherent cortical organoids in a multi-well format

    Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
    Human stem cell-derived adherent cortical organoids in 384-well plates provide a reproducible, long-term cortical organoid platform with neurons, glia, and robust network activity, enabling scalable disease modeling and therapeutic screening.
    1. Evolutionary Biology
    2. Neuroscience

    Investments in photoreceptors compete with investments in optics to determine eye design

    Francisco JH Heras, Simon B Laughlin
    Allocating space, materials and energy to an eye's optics and photoreceptor array is a major factor in eye design that explains obvious differences between simple eyes and compound eyes.
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