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    1. Structural Biology and Molecular Biophysics

    Protein Language Model Identifies Disordered, Conserved Motifs Driving Phase Separation

    Yumeng Zhang, Jared Zheng, Bin Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Neuroscience

    Heritability of movie-evoked brain activity and connectivity

    David C Gruskin, Daniel J Vieira ... Gaurav H Patel
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology

    Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers

    Mei Ling Leong, Christiane Ruedl, Klaus Karjalainen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress

    Rezwana Karim, Wendi Teng ... Hening Lin
    A cross-talk is revealed between two branches of metabolisms, amino acid limitation suppressing fatty acid biosynthesis, via posttranslational modifications of an enzyme involved in fatty acid biosynthesis.
    1. Cell Biology

    MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migratio

    Peipei Xu, Rui Zhang ... Wenxiang Meng
    MARK2-mediated phosphorylation of CAMSAP2 dynamically controls Golgi orientation by altering microtubule anchoring and polarity during directional cell migration.
    1. Cancer Biology

    KDM5 demethylases suppress R-loop-mediated “viral mimicry” and DNA damage in breast cancer cells

    Lena Lau, Kurt Henderson ... Marie Classon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Single-cell type analysis of wing premotor circuits in the ventral nerve cord of Drosophila melanogaster

    Erica Ehrhardt, Samuel C Whitehead ... Wyatt Korff
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology
    2. Developmental Biology

    Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

    Qian Wang, Hongge Li ... Xin Zhang
    FGF signaling drives lens development by recruiting Grb2 through Shc1, Frs2, and Shp2 to regulate transcription and cytoskeletal arrangements.
    1. Cancer Biology

    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

    Jie Fang, Shivendra Singh ... Jun Yang
    Drastic differences in genetic and epigenetic fitness of MYC-driven cancer cells in 3D vs 2D culture.
    Version of Record
    Research Article
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species

    Guoling Tang, Yaning Han ... Pengfei Wei
    ADPT enhances the robustness of animal pose estimation by minimizing keypoint tracking drift, enabling more accurate multi-animal tracking and facilitating refined behavioral analysis across species.
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