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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

    Bas de Boer, Thomas D Lamme ... Christopher T Schafer
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons

    Sophie R Liebergall, Ethan M Goldberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Bilateral equalization of synaptic output in olfactory glomeruli of Xenopus tadpoles

    Marta Casas, Beatrice Terni, Artur Llobet
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the recruitment of viral Type 2 IRES to ribosomal preinitiation complex for protein synthesis

    Deepakash Das, Tanweer Hussain
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Metabolic basis of the astrocyte-synapse interaction governs dopaminergic-motor connection

    Yanru Xu, Piaoping Kong ... Zhiguo Ma
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Dynamic architecture of mycobacterial outer membranes revealed by all-atom simulations

    Turner P Brown, Matthieu Chavent, Wonpil Im
    The first all-atom models of the mycobacterial outer membrane reveal how lipid organization and asymmetry generate a structurally heterogeneous barrier that underlies its unique permeability properties.
    1. Neuroscience

    Continuous flash suppression of neural responses and population orientation coding in macaque V1

    Cai-Xia Chen, Xin Wang ... Cong Yu
    Continuous flash suppression reduces V1 orientation responses in an ocular-dominance-dependent manner, which may still allow low-level coarse orientation discrimination but provide insufficient information for higher-level visual and cognitive tasks.
    1. Cancer Biology
    2. Cell Biology

    HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content

    Sara M Frangos, Henver S Brunetta ... Graham P Holloway
    Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
    1. Neuroscience

    Canonical neurodevelopmental trajectories of structural and functional manifolds

    Alicja Monaghan, Richard AI Bethlehem ... Duncan E Astle
    Contrary to prior work, principal axes of structural and functional connectivity are established early in life, remaining stable and undergoing refinement throughout development.
    1. Computational and Systems Biology

    Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability using UniDesign

    Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
    A fully computationally designed SaCas9 variant expands PAM recognition to NNNRRT, achieving up to 116-fold higher editing at noncanonical sites while matching the performance of experimentally evolved variants.
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