Browse our latest research

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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

    Richard S Marshall, Richard D Vierstra
    Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium

    Katharina Schlereth et al.
    The acquisition of vascular quiescence during transition to adulthood is driven by distinct transcriptional and epigenetic programs of pro- and anti-angiogenic genes, with the most prominent effect on the suppression of TGFß family signaling.
    1. Cell Biology
    2. Plant Biology

    Integration of two RAB5 groups during endosomal transport in plants

    Emi Ito et al.
    Plant-unique RAB5 effector 2 (PUF2) is an effector of plant-unique ARA6, which plays a key role in plant endosomal transport, integrating functions of the two plant RAB5 groups by an unprecedented mechanism.
    1. Structural Biology and Molecular Biophysics

    Microtubule assembly governed by tubulin allosteric gain in flexibility and lattice induced fit

    Maxim Igaev, Helmut Grubmüller
    A new combined mechanism explains how GTP binding by tubulin is linked to its dynamics and energetics in solution and why GTP-induced flexibility, and not the tubulin conformation as such, drives microtubule assembly.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

    Bryan A Leland et al.
    A single-cell assay reveals that the genetic rewiring that underlies PARP inhibitor resistance drives altered DNA double-strand break end resection pathway choice.