Prithvi Raj
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Ekta Rai
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Ran Song
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Shaheen Khan
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Benjamin E Wakeland
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Kasthuribai Viswanathan
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Carlos Arana
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Chaoying Liang
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Bo Zhang
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Igor Dozmorov
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Ferdicia Carr-Johnson
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Mitja Mitrovic
    
        Department of Neurology, Yale School of Medicine, New Haven, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Graham B Wiley
    
        Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Jennifer A Kelly
    
        Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Bernard R Lauwerys
    
        Pole de pathologies rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Bruxelles, Belgium
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Nancy J Olsen
    
        Division of Rheumatology, Department of Medicine, Penn State Medical School, Hershey, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Chris Cotsapas
    
        Department of Neurology, Yale School of Medicine, New Haven, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Christine K Garcia
    
        Eugene McDermott Center for Human Growth and Development, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Carol A Wise
    
        Sarah M. and Charles E. Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
John B Harley
    
        Cincinnati VA Medical Center, Cincinnati Children's Hospital Medical Center, Cincinnati, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Swapan K Nath
    
        Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Judith A James
    
        Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Chaim O Jacob
    
        Department of Medicine, University of Southern California, Los Angeles, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Betty P Tsao
    
        Department of Medicine, University of California, Los Angeles, Los Angeles, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Chandrashekhar Pasare
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
David R Karp
    
        Rheumatic Diseases Division, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Quan Zhen Li
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  
Patrick M Gaffney
    
        Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, United States
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
    
  Edward K Wakeland
    
        Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    
    
    
        Competing interests
        The authors declare that no competing interests exist.
    
 
 
    
  
      Human subjects: All the study subjects gave their written informed consent for the study. All the research protocols and methods employed were approved by UT Southwestern Institutional Review Board.
   
    
  
      © 2016, Raj et al.
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