1. Biochemistry and Chemical Biology
  2. Evolutionary Biology
Download icon

Paleoproteomics: Proteins from the past

  1. Adam F Wallace  Is a corresponding author
  2. James D Schiffbauer  Is a corresponding author
  1. University of Delaware, United States
  2. University of Missouri, United States
Cite this article as: eLife 2016;5:e20877 doi: 10.7554/eLife.20877
1 figure


Protein-mineral binding in the presence of water.

(A) The structure of SCA-1 (struthiocalcin-1): the domain that binds to mineral surfaces is rich in aspartic acid and is shown in color. (B) Molecular dynamics simulations performed by one of the present authors (AFW) predict that water molecules adjacent to the surface of calcite (CaCO3; Ca = yellow, C = cyan, O = red) form ordered layers. At least three layers of ordered water can be seen in this plot, where each blue point represents the position of a water oxygen during the simulation. Darker blues indicate regions where water is most likely to be. (C) Cartoon depicting a protein (SCA) binding to a calcite surface. By disrupting the ordered layers of water molecules (dashed blue lines) near the calcite surface, it is thought that the binding process leads to an increase in entropy (∆S > 0) which, in turn, leads to a more negative binding energy (that is, stronger binding). Demarchi et al. also hypothesize that the water molecules that remain in the ordered layers adjacent to the bound protein are prevented from participating in hydrolysis reactions that would otherwise degrade the protein.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)