The enzymes used are listed below with their accession numbers or source of publication: CfCYP76AH15, KT382358; CfCYP76AH17, KT382360; CfCYP76AH8, KT382348; CfCYP76AH11, KT382349; CfCYP76AH16, KT382359; CfCYP76AH9, KT382347; CfCYP76AH10, KT382346; CfCYP71D381, KT382342; RoFS1, AJQ30187 (Božić et al., 2015); SmCYP76AH3, KR140168 (Guo et al., 2016); RoFS2, AJQ30188 (Božić et al., 2015); SfFS, AJQ30186 (Božić et al., 2015); RoCYP76AH4, (Zi and Peters, 2013); RoCYP76AH5v1, (Zi and Peters, 2013); RoCYP76AH5v2, (Zi and Peters, 2013); RoCYP76AH6, (Zi and Peters, 2013); RoCYP76AH7, (Zi and Peters, 2013); SmCYP76AH1, AGN04215 (Guo et al., 2013); SpCYP76AH24, ALM25796 (Ignea et al., 2016a). Coleus forskohlii enzymes are indicated by a solid black triangle. CfCYP71D381 was chosen as a root because it can accept 13R-manoyl oxide as a substrate, but does not catalyze the synthesis of forskolin-related products. The number subscripts indicated at each enzyme refer to their respective enzymatic products, the structures of which are given on the right. Only the main products of each enzymes are mentioned. MO stands for manoyl oxide.