The interplay of stiffness and force anisotropies drives embryo elongation
- Sorbonne Universités, UPMC Univ Paris 06, CNRS, France
- IGBMC, CNRS (UMR7104), INSERM (U964), Université de Strasbourg, France
- Ecole Normale Supérieure, UPMC Université Pierre et Marie Curie, Université Paris Diderot, CNRS, France
- Faculté de Médecine, Université Pierre et Marie Curie-Paris, France
Peer review process
This article was accepted for publication as part of eLife's original publishing model.
History
- Version of Record published
- Accepted Manuscript updated
- Accepted Manuscript published
- Accepted
- Received
Decision letter
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K VijayRaghavanReviewing Editor; National Centre for Biological Sciences, Tata Institute of Fundamental Research, India
In the interests of transparency, eLife includes the editorial decision letter and accompanying author responses. A lightly edited version of the letter sent to the authors after peer review is shown, indicating the most substantive concerns; minor comments are not usually included.
[Editors’ note: minor issues and corrections have not been included, so there is not an accompanying Author response.]
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Reviewer #1:
This manuscript addresses the mechanobiology of cell and tissue shape changes in the context of C. elegans embryonic epidermal elongation. The authors use an impressive combination of laser surgery, live imaging, and mathematical modeling to dissect out the roles of forces and tissue stiffness in elongation. Anisotropies in stiffness in the dorsoventral epidermal cells are found to account for directed elongation in the anterior posterior axis. Without giving a precis of the entire work, this was a very rigorous investigation.
The investigation into stiffness is distinctive and sets this apart from other studies of forces in tissue shape change. From a technical standpoint the biology is complete and very high quality and I have no substantive concerns. The mathematical modeling is beyond my expertise to evaluate. However, I am impressed by the close agreement between the authors' models and their measurements.
Reviewer #2:
I read this article with great interest. It is very well written and conducted. It presents an exciting blend of results. To me the most important advance was the demonstration that the mechanical properties of tissue play a significant role in embryonic elongation. The mix of modelling and experimental results brings out most impressive results. The paper should be published as is in my opinion.
https://doi.org/10.7554/eLife.23866.025
