Method for identification of condition-associated public antigen receptor sequences
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Russian Federation
- École Normale Supérieure, France
Abstract
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type 1 diabetes responsive TCRβ sequences.
Data availability
Article and author information
Author details
Dmitriy M Chudakov
Aleksandra M Walczak
Funding
Russian Science Foundation (15-15-00178)
- Dmitriy M Chudakov
- Ilgar Z Mamedov
- Yuri B Lebedev
European Research Council (724208)
- Aleksandra M Walczak
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Arup K Chakraborty, Massachusetts Institute of Technology, United States
Version history
- Received: October 24, 2017
- Accepted: March 12, 2018
- Accepted Manuscript published: March 13, 2018 (version 1)
- Version of Record published: March 28, 2018 (version 2)
Copyright
© 2018, Pogorelyy et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Method for identification of condition-associated public antigen receptor sequences
eLife 7:e33050.
https://doi.org/10.7554/eLife.33050
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