Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type 1 diabetes responsive TCRβ sequences.
- Dmitriy M Chudakov
- Ilgar Z Mamedov
- Yuri B Lebedev
- Aleksandra M Walczak
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Arup K Chakraborty, Reviewing Editor, Massachusetts Institute of Technology, United States
- Received: October 24, 2017
- Accepted: March 12, 2018
- Accepted Manuscript published: March 13, 2018 (version 1)
© 2018, Pogorelyy et al.
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