1. Microbiology and Infectious Disease
  2. Structural Biology and Molecular Biophysics
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Viruses: The secrets of the stability of the HIV-1 capsid

  1. Martin Obr  Is a corresponding author
  2. Hans-Georg Kräusslich  Is a corresponding author
  1. Heidelberg University, Germany
Cite this article as: eLife 2018;7:e38895 doi: 10.7554/eLife.38895
1 figure


Molecular structure of the HIV-1 capsid and the small molecule IP6 binding to the R18 pore.

(A) Transmission electron microscopy image of an authentic negative stained HIV-1 capsid. The capsid is formed of hundreds of CA proteins organized in hexamers and pentamers. (B). The structure of a CA hexamer, revealed by X-ray crystallography (PDB ID: 3H47). (C). Detail of the small molecule IP6 (IP6; in the center) binding to a ring of six arginines (R18; on the outside) within the R18 pore at the center of a CA hexamer. IP6 contains six negatively charged phosphate groups , which are coordinated by the positively charged guanidino groups of the R18 side chains. Dashed lines indicate interactions between the guanidino and phosphate groups (Panel C is adapted from Mallery et al., 2018).

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