1. Biochemistry and Chemical Biology
  2. Developmental Biology
Download icon

Thalidomide: Unlocking a dark past

  1. Fernando Rodríguez-Pérez
  2. Michael Rape  Is a corresponding author
  1. University of California, United States
Insight
Cite this article as: eLife 2018;7:e41002 doi: 10.7554/eLife.41002
1 figure

Figures

Thalidomide, the transcription factor SALL4 and limb defects.

(A) In the absence of an immunomodulatory drug like thalidomide the CUL4CRBN complex (multiple colors) 'tags' a substrate (purple) for degradation by the proteasome (pale blue). SALL4 remains intact during this process and is therefore able to control the transcriptional activity of target genes to control robust embryonic limb development. (B) The presence of thalidomide results in SALL4 being tagged for degradation. The subsequent absence of SALL4 prevents the transcription of its target genes and thus likely interferes with limb development, as observed in thalidomide syndrome. iMiD: immunomodulatory drug.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)