1. Evolutionary Biology
  2. Genetics and Genomics
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Ancient origins of arthropod moulting pathway components

  1. André Luiz de Oliveira
  2. Andrew Calcino
  3. Andreas Wanninger  Is a corresponding author
  1. University of Vienna, Austria
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Cite this article as: eLife 2019;8:e46113 doi: 10.7554/eLife.46113

Abstract

Ecdysis (moulting) is the defining character of Ecdysoza (arthropods, nematodes and related phyla). Despite superficial similarities, the signalling cascade underlying moulting differs between Panarthropoda and the remaining ecdysozoans. Here, we reconstruct evolution of major components of the ecdysis pathway. Its key elements evolved much earlier than previously thought and are present in non-moulting lophotrochozoans and deuterostomes. Eclosion hormone (EH) and bursicon originated prior to the cnidarian-bilaterian split, whereas ecdysis-triggering hormone (ETH) and crustacean cardioactive peptide (CCAP) evolved in the bilaterian last common ancestor (LCA). Identification of EH, CCAP and bursicon in Onychophora and EH, ETH and CCAP in Tardigrada suggests that the pathway was present in the panarthropod LCA. Trunk, an ancient extracellular signalling molecule and a well-established paralog of the insect peptide prothoracicotropic hormone (PTTH), is present in the non-bilaterian ctenophore Mnemiopsis leidyi. This constitutes the first case of a ctenophore signalling peptide with homology to a neuropeptide.

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Author details

  1. André Luiz de Oliveira

    Department of Integrative Zoology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-3542-4439
  2. Andrew Calcino

    Department of Integrative Zoology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
    Competing interests
    The authors declare that no competing interests exist.
  3. Andreas Wanninger

    Department of Integrative Zoology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
    For correspondence
    andreas.wanninger@univie.ac.at
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-3266-5838

Funding

Austrian Science Fund (P29455-B29)

  • Andreas Wanninger

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (6090/13-3)

  • André Luiz de Oliveira

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. K VijayRaghavan, National Centre for Biological Sciences, Tata Institute of Fundamental Research, India

Publication history

  1. Received: February 14, 2019
  2. Accepted: June 27, 2019
  3. Accepted Manuscript published: July 3, 2019 (version 1)

Copyright

© 2019, de Oliveira et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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