1. Epidemiology and Global Health
  2. Microbiology and Infectious Disease
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Impact of community piped water coverage on re-infection with urogenital schistosomiasis in rural South Africa

  1. Polycarp Mogeni  Is a corresponding author
  2. Alain Vandormael
  3. Diego Cuadros
  4. Christopher Appleton
  5. Frank Tanser
  1. African Health Research Institute, South Africa
  2. University of KwaZulu-Natal, South Africa
  3. University of Cincinnati, United States
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Cite this article as: eLife 2020;9:e54012 doi: 10.7554/eLife.54012

Abstract

Previously, we demonstrated that high coverage of piped water in the seven years preceding a parasitological survey was strongly predictive of Schistosomiasis haematobium infection in a nested cohort of 1,976 primary school children [1]. Here, we report on the prospective follow up of infected members of this nested cohort (N=333) for two successive rounds following treatment. Using a negative binomial regression fitted to egg count data, we found that every percentage point increase in piped water coverage was associated with 4.4% decline in intensity of re-infection (incidence rate ratio = 0.96, 95%CI: 0.93-0.98, P= 0.002) among the treated children. We therefore provide further compelling evidence in support of the scaleup of piped water as an effective control strategy against Schistosomiasis haematobium transmission.

Article and author information

Author details

  1. Polycarp Mogeni

    Epidemiology, African Health Research Institute, Durban, South Africa
    For correspondence
    pkambona11@gmail.com
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-1926-7576
  2. Alain Vandormael

    School of Nursing, University of KwaZulu-Natal, Durban, South Africa
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-5742-0511
  3. Diego Cuadros

    Geography, University of Cincinnati, Cincinnati, United States
    Competing interests
    The authors declare that no competing interests exist.
  4. Christopher Appleton

    School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa
    Competing interests
    The authors declare that no competing interests exist.
  5. Frank Tanser

    School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-9797-0000

Funding

National Institutes of Health

  • Christopher Appleton
  • Frank Tanser

Wellcome

  • Frank Tanser

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Human subjects: Ethical approval was provided by the Biomedical Research Ethics Committee of the university of KwaZulu-Natal (reference #E165/05). Written informed consent was sought from parents or guardians of the participating children for both rounds of follow-up in 2007 and 2008 and assent obtained from the children during the follow-up surveys.

Reviewing Editor

  1. Eduardo Franco, McGill University, Canada

Publication history

  1. Received: November 29, 2019
  2. Accepted: March 10, 2020
  3. Accepted Manuscript published: March 17, 2020 (version 1)
  4. Version of Record published: March 31, 2020 (version 2)

Copyright

© 2020, Mogeni et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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