Metapopulation ecology links antibiotic resistance, consumption, and patient transfers in a network of hospital wards
- University of Lyon, France
- Hospices Civils de Lyon, France
- CNRS, France
Abstract
Antimicrobial resistance (AMR) is a global threat. A better understanding of how antibiotic use and between-ward patient transfers (or connectivity) impact population-level AMR in hospital networks can help optimize antibiotic stewardship and infection control strategies. Here, we used a metapopulation framework to explain variations in the incidence of infections caused by 7 major bacterial species and their drug-resistant variants in a network of 357 hospital wards. We found that ward-level antibiotic consumption volume had a stronger influence on the incidence of the more resistant pathogens, while connectivity had the most influence on hospital-endemic species and carbapenem-resistant pathogens. Piperacillin-tazobactam consumption was the strongest predictor of the cumulative incidence of infections resistant to empirical sepsis therapy. Our data provide evidence that both antibiotic use and connectivity measurably influence hospital AMR. Finally, we provide a ranking of key antibiotics by their estimated population-level impact on AMR that might help inform antimicrobial stewardship strategies.
Data availability
All data and software code that support the findings of this study are available at: https://github.com/rasigadelab/metapop.
Article and author information
Author details
Jean-Philippe Rasigade
Funding
Fondation Innovations en Infectiologie (R18037CC)
- Jean-Philippe Rasigade
French Laboratory of Excellence project ECOFECT (ANR-11-LABX-0048)
- Julie Teresa Shapiro
- Gilles Leboucher
- François Vandenesch
- Jean-Philippe Rasigade
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Copyright
© 2020, Shapiro et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 1,745
- views
-
- 268
- downloads
-
- 6
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Metapopulation ecology links antibiotic resistance, consumption, and patient transfers in a network of hospital wards
eLife 9:e54795.
https://doi.org/10.7554/eLife.54795
