Plasma proteomic biomarker signature of age predicts health and life span
Abstract
Older age is a strong shared risk factor for many chronic diseases and there is increasing interest in identifying aging biomarkers. Here a proteomic analysis of 1301 plasma proteins was conducted in 997 individuals between 21 and 102 years of age. We identified 651 proteins associated with age (506 over-represented, 145 underrepresented with age) was identified. Mediation analysis suggested a role for partial cis-epigenetic control of protein expression with age. Of the age-associated proteins, 33.5% and 45.3%, were associated with mortality and multimorbidity, respectively. There was enrichment of proteins associated with inflammation and extracellular matrix as well as senescence-associated secretory proteins. A 76-protein proteomic age signature predicted accumulation of chronic diseases and all-cause mortality. These data support the premise of proteomic biomarkers to monitor aging trajectories and to identify individuals at higher risk for disease to be targeted for in depth diagnostic procedures and early interventions.
Data availability
Phenotypic data and source codes used for this manuscript is provided. Due to the contents of the InCHIANTI study consent forms, proteomic and DNA methylation data cannot be made publicly available. Researchers can seek access to these data through the submission of proposals and subsequent approval through the InCHIANTI study website (inchiantistudy.net).
Article and author information
Author details
Funding
National Institutes of Health (U01 AG060906)
- Birgit Schilling
National Institutes of Health (K99 AG065484)
- Nathan Basisty
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Sara Hägg, Karolinska Institutet, Sweden
Ethics
Human subjects: The study protocol (exemption #11976) was approved by the Italian National Institute of Research and Care of Aging Institutional Review and Medstar Research Institute (Baltimore, MD) and approved by the Internal Review Board of the National Institute for Environmental Health Sciences (NIEHS).
Version history
- Received: July 15, 2020
- Accepted: November 16, 2020
- Accepted Manuscript published: November 19, 2020 (version 1)
- Version of Record published: December 8, 2020 (version 2)
Copyright
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
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