1. Cancer Biology
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Toxicity: Fishing for protective compounds

  1. Giuliano Ciarimboli  Is a corresponding author
  1. Experimental Nephrology, Med. Clinic D, Muenster University Hospital, Germany
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Cite this article as: eLife 2020;9:e61547 doi: 10.7554/eLife.61547
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Protective effects of dopamine and L-mimosine against the cancer drug cisplatin.

Treatment of zebrafish larvae with cisplatin (panel A) impairs the function (lightning bolt icon) of the fish's primitive kidney (pronephros), and of its anterior and posterior lateral line – the organs that display hair cells similar to the ones found in ears. Application of dopamine or L-mimosine (panel B) suppresses the toxic effects of cisplatin.

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