1. Chromosomes and Gene Expression
  2. Medicine
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Cardiovascular Disease: Exploring risk factors at the molecular level

  1. Martina Rudnicki  Is a corresponding author
  2. Tara L Haas  Is a corresponding author
  1. Faculty of Health, York University, Canada
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Cite this article as: eLife 2021;10:e68271 doi: 10.7554/eLife.68271
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Cardiovascular diseases and cardiac endothelial cells.

Hemanthakumar et al. show that risk factors for cardiovascular diseases (red) trigger molecular changes (red arrows) in cardiac endothelial cells (top cell in the central circle). This increases the expression levels of genes related to cellular aging (bottom right) and mesenchymal identity (bottom left). Exercise (blue) can protect against cardiovascular diseases by repressing these molecular changes (blue flat-ended arrow). Figure created using BioRender.com.

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