1. Cancer Biology
  2. Genetics and Genomics
Download icon

Risk Modeling: Predicting cancer risk based on family history

  1. Michelle F Jacobs  Is a corresponding author
  1. Internal Medicine, University of Michigan, United States
Insight
Cite this article as: eLife 2021;10:e73380 doi: 10.7554/eLife.73380
1 figure

Figures

Workflow for PanelPRO.

First, information on family history, including cancer diagnoses, age of relatives, and cancer risk factors is added into the risk modeling software PanelPRO (input, blue box on the left). Then, PanelPRO validates data formatting (preprocessing, grey oval), and analyses information about frequency and cancer risks for family cancer syndromes (algorithm, grey box) to estimate the likelihood of a person in a family having a mutation in a gene linked to an increased risk of cancer (output, green box on the right). Mutation probability and cumulative cancer risk are given as a probability between 0.0 (no risk) and 1.0 (100% risk).

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)