Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry

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Abstract

Scene and object information reach the entorhinal-hippocampal circuitry in partly segregated cortical processing streams. Converging evidence suggests that such information-specific streams organize the cortical - entorhinal interaction and the circuitry's inner communication along the transversal axis of hippocampal subiculum and CA1. Here, we leveraged ultra-high field functional imaging and advance Maass, Berron et al. (2015) who report two functional routes segregating the entorhinal cortex (EC) and the subiculum. We identify entorhinal subregions based on preferential functional connectivity with perirhinal Area 35 and 36, parahippocampal and retrosplenial cortical sources (referred to as EC_Area35-based, EC_Area36-based, EC_PHC-based, EC_RSC-based, respectively). Our data show specific scene processing in the functionally connected EC_PHC-based and distal subiculum. Another route, that functionally connects the EC_Area35-based and a newly identified EC_RSC-based with the subiculum/CA1 border, however, shows no selectivity between object and scene conditions. Our results are consistent with transversal information-specific pathways in the human entorhinal-hippocampal circuitry, with anatomically organized convergence of cortical processing streams and a unique route for scene information. Our study thus further characterizes the functional organization of this circuitry and its information-specific role in memory function.

Data availability

Source data that contain numerical data used to generate Figure 2, Figure 3, Figure 4, Appendix 1 Figure 2, Appendix 1 Figure 3, Appendix 1 Figure 4, Appendix 5 Figure 1 as well as group-level statistical maps (referred to as Source Code 1-16) that underlie Figure 1, Figure 2, Appendix 1 Figure 1, Appendix 1 Figure 2, Appendix 3 Figure 1, Appendix 3 Figure 2 and Appendix 4 Figure 1 have been provided under:Open Science Framework. ID 9v3qp. https://osf.io/9v3qp

The following data sets were generated

1. Grande X
2. Berron D
(2022) Source Data from Functional Connectivity and Information Processing in the Entorhinal-Hippocampal Circuitry
Open Science Framework. ID 9v3qp.

https://osf.io/9v3qp

Article and author information

Author details

Xenia Grande

German Center for Neurodegenerative Diseases, Magdeburg, Germany

For correspondence
xenia.grande@dzne.de

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0002-2486-3201
Magdalena M Sauvage

Functional Architecture of Memory Department, Leibniz Institute for Neurobiology, Magdeburg, Germany

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0002-7586-6410
Andreas Becke

Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany

Competing interests
The authors declare that no competing interests exist.
Emrah Düzel

Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany

Competing interests
The authors declare that no competing interests exist.
David Berron

German Center for Neurodegenerative Diseases, Magdeburg, Germany

For correspondence
david.berron@dzne.de

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0003-1558-1883

Funding

Horizon 2020 Research and Innovation Programme (785907 (HBP SGA2) and 945539 (HBP SGA3))

Emrah Düzel

Deutsche Forschungsgemeinschaft (Project-ID 42589994)

Magdalena M Sauvage
Emrah Düzel

HORIZON EUROPE Marie Sklodowska-Curie Actions (843074)

David Berron

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Human subjects: Informed consent and consent to publish was obtained from human participants.The study received approval by the ethics committee of Otto-von-Guericke University, Magdeburg (Germany) under reference number 128/14.

Copyright

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.