Dynamics and maintenance of categorical responses in primary auditory cortex during task engagement
Abstract
Grouping sets of sounds into relevant categories is an important cognitive ability that enables the association of stimuli with appropriate goal-directed behavioral responses. In perceptual tasks, the primary auditory cortex (A1) assumes a prominent role by concurrently encoding both sound sensory features and task-related variables. Here we sought to explore the role of A1 in the initiation of sound categorization, shedding light on its involvement in this cognitive process. We trained ferrets to discriminate click trains of different rates in a Go/No-Go delayed categorization task and recorded neural activity during both active behavior and passive exposure to the same sounds. Purely categorical response components were extracted and analyzed separately from sensory responses to reveal their contributions to the overall population response throughout the trials. We found that categorical activity emerged during sound presentation in the population average and was present in both active behavioral and passive states. However, upon task engagement, categorical responses to the No-Go category became suppressed in the population code, leading to an asymmetrical representation of the Go stimuli relative to the No-Go sounds and prestimulus baseline. The population code underwent an abrupt change at stimulus offset, with sustained responses after the Go sounds during the delay period. Notably, the categorical responses observed during the stimulus period exhibited a significant correlation with those extracted from the delay epoch, suggesting an early involvement of A1 in stimulus categorization.
Data availability
Data is available on Zenodo, DOI: 10.5281/zenodo.8371083.
Article and author information
Author details
Funding
Agence Nationale de la Recherche (ANR-17-EURE-0017)
- Rupesh K Chillale
- Shihab Shamma
- Srdjan Ostojic
- Yves Boubenec
Agence Nationale de la Recherche (ANR-10-IDEX-0001-02)
- Rupesh K Chillale
- Shihab Shamma
- Srdjan Ostojic
- Yves Boubenec
Agence Nationale de la Recherche (ANR-JCJC-DynaMiC)
- Yves Boubenec
H2020 European Research Council (ERC 787836-NEUME)
- Shihab Shamma
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: Experiments were approved by the French Ministry of Agriculture (protocol authorization: 21022) andstrictly comply with the European directives on the protection of animals used for scientific purposes(2010/63/EU).
Reviewing Editor
- Andrew J King, University of Oxford, United Kingdom
Version history
- Received: December 20, 2022
- Accepted: November 12, 2023
- Accepted Manuscript published: November 16, 2023 (version 1)
Copyright
© 2023, Chillale et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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