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    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling

    Caleb Hallinan, Hyun Joo Ji ... Jean Fan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Physics of Living Systems

    Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton

    Takaki Yamamoto, Tomoki Ishibashi ... Tatsuo Shibata
    Molecular chirality of actomyosin induces cell-scale chiral rotation without requiring a chiral arrangement of actomyosin filaments, revealing a key mechanism of cell chirality underlying left–right asymmetric tissue development.
    1. Neuroscience

    Adaptation invariant concentration discrimination in an insect olfactory system

    Doris Ling, Lijun Zhang ... Baranidharan Raman
    The combination of neurons activated by an odorant robustly maintains information about stimulus intensity in an adaptation-invariant fashion.
    1. Neuroscience

    Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

    Katerina Rademacher, Zak Doric ... Ken Nakamura
    Following chronic hyperactivation using chemogenetics, vulnerable substantia nigra dopamine neurons display progressive degeneration unlike neighboring ventral tegmental area dopamine neurons.
    1. Developmental Biology

    Spectraplakin cooperates with noncentrosomal microtubule regulators to orient dendritic microtubules in Drosophila

    Matthew Davies, Neeraja Sanal ... Sebastian Rumpf
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    Systematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

    Hao Jiang, Jimena Druker ... Angus I Lamond
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multiple modes of cholesterol translocation in the human Smoothened receptor

    Prateek D Bansal, Maia Kinnebrew ... Diwakar Shukla
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Evolutionary Biology

    Faroese Whole Genomes Provide Insight into Ancestry and Recent Selection

    Iman Hamid, Ólavur Mortensen ... Noomi O Gregersen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the recruitment of viral Type 2 IRES to ribosomal preinitiation complex for protein synthesis

    Deepakash Das, Tanweer Hussain
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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