Figure 1—figure supplement 1. | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

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A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

Figure 1—figure supplement 1.

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Champalimaud Foundation, Portugal
Figure 1—figure supplement 1.
Download figureOpen in new tabFigure 1—figure supplement 1. LocoMouse tracking validation.

(A) Comparison of manual (gray) and automated tracking (blue) for front left paw across 3 dimensions. From left to right, plots show normalized x, y, and z paw position aligned to stance onset (n = 43 strides from 9 movies of 3 mice). (B) Scatterplots of manual vs automated tracking positions (x, y, and z) for all frames (n = 4194) of the same 9 movies. Values where the difference between manual and automated tracking are larger than average paw size are color-coded in green. Correlation coefficients are Pearson's r. (C) Example tracking traces demonstrate that stride lengths can differ at similar walking speeds due to pauses in walking.

DOI: http://dx.doi.org/10.7554/eLife.07892.004