Table 3. | Modulation of anxiety and fear via distinct intrahippocampal circuits

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Modulation of anxiety and fear via distinct intrahippocampal circuits

Table 3.

Affiliation details

McLean Hospital, United States; Harvard Medical School, United States; The University of Tennessee Health Science Center, United States; Yale School of Medicine, United States; Russian Academy of Sciences, Russia; University of Zurich, Switzerland
Table 3.

Results of omnibus statistical tests of measured parameters in behavioral tests of fear.

DOI: http://dx.doi.org/10.7554/eLife.14120.017

1. Fear-Potentiated Startle
Within-Genotype Comparisons
Two-Way Factorial ANOVA; Factors: Tone/No Tone (within-subjects), Drug (between-subjects)
α2F/Fα2CA1KO
ToneF(1,28)=33.75p<0.001F(1,20)=49.17p<0.001
DrugF(1,28)=0.30p=0.59F(1,20)=0.51p=0.48
Tone x Drug InteractionF(1,28)=9.95p=0.004F(1,20)=0.02P=0.89
α2CA3KOα2DGKO
ToneF(1,18)=16.60p<0.001F(1,20)=54.46p<0.001
DrugF(1,18)=0.09p=0.77F(1,20)=0.73p=0.40
Tone x Drug InteractionF(1,18)=5.16p=0.04F(1,20)=10.24p=0.01
Between-Genotype Comparisons
Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects)
% FPS
GenotypeF(3,86)=1.17p=0.91
DrugF(1,86)=16.69p<0.001
Genotype x Drug InteractionF(3,86)=2.44p=0.07
2. Vogel Conflict Test
Pretest (Unpunished) Drinking
One-Way ANOVA; Factor: Genotype (between-subjects)
Number of licks
GenotypeF(3,63)=0.63p=0.60
Test (Punished) Drinking
Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects)
Number of licks
GenotypeF(3,59)=1.00p=0.40
DrugF(1,59)=14.57p<0.001
Genotype x Drug InteractionF(3,59)=1.21p=0.31