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    1. Evolutionary Biology

    Mathematical model predicts effect of bacterial mutations on antibiotic success

    Findings suggest measuring the number of mutations that lead to antibiotic resistance in bacteria is crucial for determining how likely antibiotics are to fail, and should be used to inform new treatment strategies aimed at preventing resistance evolution.
    1. Medicine

    New model helps predict heart attacks in high-risk patients

    Researchers have described a new approach to analysing the forces at play behind diseased heart vessels, which could help cardiologists predict heart attacks in patients.
  1. eLife extends support for Coko’s work on open-source publishing solutions

    eLife and Coko will continue working together on new systems and approaches to research communication.
    1. Cancer Biology

    Low-dose, four-drug combo blocks cancer spread in mice

    A new approach to preventing cancer spread that uses a combination of low-dose, metastasis-inhibiting drugs shows promise in mouse studies and may help prevent drug resistance or relapse.
    1. Computational and Systems Biology
    2. Medicine

    Map of metabolic changes after heart attack holds clues to recovery

    Researchers have constructed a map of metabolic changes that occur across multiple tissues after a heart attack in the hope of finding targets for better treatments.
  2. Media Coverage: April roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in April 2021, including Scientific American, the Daily Mail and the Hindustan Times.
    1. Computational and Systems Biology
    2. Medicine

    Why does heart scarring cause abnormal rhythms in some people but not others?

    People with stroke without atrial fibrillation have the same heart scar tissue as those with atrial fibrillation but may be lacking the triggers that cause heart rhythm disorders.
    1. Computational and Systems Biology

    Changes in proteins play important role in aging kidneys

    Researchers have shown that examining both protein changes and the transcription of genes in kidneys provides a more complete picture of the aging process in these organs.
    1. Genetics and Genomics

    Do people aged 105 and over live longer because they have more efficient DNA repair?

    Whole-genome sequencing of people who live beyond 105 and 110 years reveals unique genetic signatures linked to protective processes such as DNA repair.
    1. Medicine
    2. Neuroscience

    Researchers find mechanism underlying muscle weakness in Becker disease

    Study identifies the mechanisms that cause muscle weakness experienced by people with Becker disease, providing options for possible new therapies.