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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    How high-intensity interval training can reshape metabolism

    Findings in men reveal how skeletal muscle adapts to high-intensity interval training, which includes changes to processes that are important for regulating metabolism and muscle contraction.
    1. Epidemiology and Global Health
    2. Medicine

    Type 2 diabetes accelerates brain aging and cognitive decline

    Analysis of UK Biobank data from 20,000 people shows that diabetes speeds up the normal process of brain aging, with longer duration of diabetes linked to increased neurodegeneration.
    1. Biochemistry and Chemical Biology
    2. Epidemiology and Global Health

    How eating eggs can boost heart health

    A study shows that eating eggs can boost the number of heart-healthy metabolites in the blood, which may partially explain the protective effect of moderate egg consumption on cardiovascular disease.
    1. Computational and Systems Biology
    2. Medicine

    Early warning system forecasts who needs critical care for COVID-19

    An algorithm can accurately predict which hospitalised patients are at the highest risk of death and require critical care, regardless of immune protection status and virus variant.
    1. Medicine
    2. Neuroscience

    Concussion symptoms in children may have multiple underlying causes

    A study suggests there are multiple ways that brain damage caused by paediatric concussions can lead to different sets of symptoms, and this complexity can be missed by conventional study approaches.
    1. Cancer Biology
    2. Developmental Biology

    Study identifies potential target for treating childhood blood cancer

    Research into a type of blood cancer called juvenile myelomonocytic leukaemia suggests anti-inflammatory treatment as a possible new therapy for the disease.
    1. Biochemistry and Chemical Biology

    Marine sponge chemical and synthetic derivatives hijack human enzyme to kill cells

    New insights on how a human enzyme that converts chemicals produced by marine sponges and optimised synthetic derivatives into cell-killing compounds could aid the development of new anti-cancer or anti-infection drugs.
  1. Media coverage: April roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in April 2022, including BBC News, Sky News and The Sun.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Scientists identify genetic variants linked to mobility changes in aging

    Genetic variants in an enzyme that is important to mitochondrial function may contribute to whether individuals maintain or lose strength and mobility as they age.
  2. eLife welcomes Fiona Hutton as new Head of Publishing

    A long-time advocate for open science, Hutton will lead eLife’s transformation to a ‘publish, then review’ model that puts preprints first.