Jeffrey C Erlich, Bingni W Brunton ... Carlos D Brody
Quantitative modeling of inactivations shows the prefrontal cortex (but not parietal cortex) of the rat is obligatory for decisions guided by evidence accumulating longer than 240 ms.
From as early as primary visual cortex and across posterior cortical areas, neural responses to visual pulses during an evidence-accumulation task exhibit a multitude of task-related amplitude modulations/gain changes.
Sensory-evidence accumulation is a distributed cortical computation, but frontal cortical areas contribute to accumulation on longer timescales than posterior cortical areas.
Niels A Kloosterman, Jan Willem de Gee ... Johannes Jacobus Fahrenfort
Decision-makers are able to intentionally control neural excitability to strategically bias sensory evidence accumulation towards the decision bound that maximizes reward within a given ecological context.
Anna C Geuzebroek, Hannah Craddock ... Simon P Kelly
In order to adjust for expected difficulty level while detecting unpredictably timed target within continuous streams of noisy information, people regulate the transfer of the sensory inputs to the accumulation process.
Ciara A Devine, Christine Gaffney ... Redmond G O'Connell
Temporal uncertainty interferes with the timely onset of evidence accumulation in perceptual decision making prompting the brain to rely instead on statistical regularities in the temporal structure of the environment.
Andrei S Avanesov, Siming Ma ... Vadim N Gladyshev
Aging is a process characterized by gradual metabolome remodeling, deceleration of the remodeling in late life and under conditions that extend lifespan, and a mortality-associated pattern of cumulative damage.
In parallel to protein-driven processes, characteristic physicochemical properties of the endoplasmic reticulum membrane modulate intracellular fat accumulation and lipid droplet formation.
Interactions between cortical and subcortical circuits in the mammalian brain flexibly control the flow of information streams that drive decisions by shifting the balance of power both within and between action representations.
Ashelyn E Sidders, Katarzyna M Kedziora ... Brian P Conlon
Palmitoleic acid not only potentiates vancomycin killing of Gram-positive bacteria, but the insertion of palmitoleic acid into the membrane leads to the unexpected accumulation of membrane-bound cell wall precursors, representing a novel mechanism of action for unsaturated fatty acids.