5,091 results found
    1. Physics of Living Systems

    Phenotyping single-cell motility in microfluidic confinement

    Samuel A Bentley, Hannah Laeverenz-Schlogelhofer ... Kirsty Y Wan
    A droplet microfluidics approach to stably trap and phenotype individual micron-sized algae reveals their distinct but stereotyped movement patterns and how they respond in real time to local environmental cues, including novel boundary circling behaviour under strong confinement.
    1. Neuroscience

    Enteroendocrine cell lineages that differentially control feeding and gut motility

    Marito Hayashi, Judith A Kaye ... Stephen D Liberles
    Intersectional genetic tools are used for selective control of enteroendocrine cell subtypes in vivo, revealing their differential roles in gut physiology and feeding behavior.
    1. Developmental Biology

    Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny

    Michèle Romanos, Guillaume Allio ... Bertrand Bénazéraf
    Spatial variations of transcription factor expression regulate the choice of progenitors to stay in their niche or to migrate into neural and mesodermal tissues.
    1. Cell Biology
    2. Immunology and Inflammation

    Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility

    Tobias X Dong, Shivashankar Othy ... Michael D Cahalan
    Orai1 channels activate intermittently in motile T cells, generating calcium transients, detected by a novel genetically encoded indicator and inducing pauses that favor antigen scanning.
    1. Physics of Living Systems

    Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo

    Elizabeth R Jerison, Stephen R Quake
    Motile interstitial T cells in live zebrafish access a broad range of length-scales due to long-lived cell-intrinsic variation in speed, and a coupling between speed and directional persistence.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Three F-actin assembly centers regulate organelle inheritance, cell-cell communication and motility in Toxoplasma gondii

    Nicolò Tosetti, Nicolas Dos Santos Pacheco ... Damien Jacot
    Toxoplasma gondii formins have several non-overlapping roles including generating an apico-basal flux of F-actin that is controlled by phosphorylation and methylation and is essential for motility.
    1. Physics of Living Systems

    Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

    Monika E Dolega, Sylvain Monnier ... Giovanni Cappello
    Theoretical predictions and experiments on multicellular aggregates indicate that the extracellular matrix acts as a mechanical sensor, which regulates cell proliferation and migration in a three-dimensional environment.
    1. Microbiology and Infectious Disease

    A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

    Sofiene Seef, Julien Herrou ... Tâm Mignot
    First identification of the molecular determinants driving contact-dependent predation in Myxococcus..
    1. Cell Biology
    2. Immunology and Inflammation

    Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility

    Akira Takeda, Daichi Kobayashi ... Eiji Umemoto
    A lipid mediator lysophosphatidic acid (LPA) derived from fibroblastic reticular cells regulates T-cell movement through the densely packed reticular network in lymph nodes in a manner dependent on the LPA receptor LPA2-ROCK-myosin II.
    1. Microbiology and Infectious Disease

    Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector

    Lei Song, Jingjing Luo ... Zhao-Qing Luo
    A novel bacterial protease activated by a eukaryote-specific factor attacks a host protein involved in cytoskeleton organization to inhibit cell migration during Legionella pneumophila infection.

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