Predicted gene regulatory networks active in planarians adult stem cells provide testable hypotheses about the control of pluripotency and differentiation in animals.

A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.

Single-cell RNA sequencing identifies an adult regional gene expression map in planarian muscle that includes two FGFRL-Wnt circuits controlling head and trunk tissue pattern.

Loss of a single organ, the planarian pharynx, triggers immediate proliferation and expansion of stem cells required to replace it.

A combination of experimental and theoretical analysis identifies body size-dependent energy storage as the physiological cause of 3/4-power law scaling of the metabolic rate in planarians.

Application of laser-capture microdissection to planarian intestinal tissue provides a new tool for analysis of tissue-specific gene expression in flatworms, and a new resource to advance investigations of gastrointestinal regeneration.

Hedgehog signaling plays a role in regulating glia gene expression in planarians, pointing to a candidate ancestral and broadly used role for the Hedgehog pathway.

NR4A is a broadly conserved transcription factor that is required for concordance of patterning information and anatomy at both ends of the planarian anterior-posterior axis.

Planarian brain neurons modulate their turnover by signaling to nearby stem cells.

The planarian mex3-1 gene is required for non-stem cell fates and suppresses a stem cell fate in differentiating cells.