A damaging form of positive feedback linking elevated calcium levels and metabotropic glutamate receptor function in Purkinje neurons plays a critical role in the pathology in spinocerebellar ataxias.
Renat N Khaliullin, Rebecca A Green ... Karen Oegema
Positive feedback between contractile ring myosin and compression-driven cortical flow can explain the exponential accumulation of contractile ring components and constriction rate acceleration that ensures timely cell separation during cytokinesis.
Ines Alvarez-Rodrigo, Thomas L Steinacker ... Jordan W Raff
Polo kinase recruitment by the protein Spd-2 to the pericentriolar scaffold is a key element of the positive feedback loop which drives the expansion of the mitotic centrosomes in flies.
Optogenetic control of Cdc42 activation during polarization of budding yeast demonstrates a cell cycle regulated switch between two distinct modes of positive feedback.
A subset of the zebrafish Nodal receptor complex is regulated by positive feedback and controls the diffusion and distribution of Nodal signals during germ layer formation.
The interplay between the Flower Ca2+ channel and PI(4,5)P2 spatiotemporally couples synaptic vesicle exocytosis to activity-dependent bulk endocytosis and synaptic vesicle reformation from bulk endosomes.
Takayoshi Yamamoto, Yuta Kambayashi ... Stefan Hoppler
Biomolecular experiments and computer simulations revealed that morphogen receptors expressed via a positive feedback loop impart robustness against variations in morphogen secretion rate and speed of development.
Isaac Cervantes-Sandoval, Anna Phan ... Ronald L Davis
Structural and functional analysis of axonal-axonal reciprocal connections between dopamine neurons and Kenyon cells provides insight into the brain computations for normal associative olfactory learning.