4,097 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe

    Anneke Hibbel, Aliona Bogdanova ... Jonathon Howard
    The budding yeast kinesin Kip2 is a polymerase that uses its processive motility in a positive feedback loop to promote microtubule growth.
    Short Report Updated
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    1. Neuroscience

    A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2

    Pratap Meera, Stefan Pulst, Thomas Otis
    A damaging form of positive feedback linking elevated calcium levels and metabotropic glutamate receptor function in Purkinje neurons plays a critical role in the pathology in spinocerebellar ataxias.
    1. Cell Biology
    2. Computational and Systems Biology

    A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans

    Renat N Khaliullin, Rebecca A Green ... Karen Oegema
    Positive feedback between contractile ring myosin and compression-driven cortical flow can explain the exponential accumulation of contractile ring components and constriction rate acceleration that ensures timely cell separation during cytokinesis.
    1. Cell Biology

    Evidence that a positive feedback loop drives centrosome maturation in fly embryos

    Ines Alvarez-Rodrigo, Thomas L Steinacker ... Jordan W Raff
    Polo kinase recruitment by the protein Spd-2 to the pericentriolar scaffold is a key element of the positive feedback loop which drives the expansion of the mitotic centrosomes in flies.
    1. Cell Biology

    Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization

    Kristen Witte, Devin Strickland, Michael Glotzer
    Optogenetic control of Cdc42 activation during polarization of budding yeast demonstrates a cell cycle regulated switch between two distinct modes of positive feedback.
    1. Developmental Biology

    Regulation of Nodal signaling propagation by receptor interactions and positive feedback

    Hannes Preiß, Anna C Kögler ... Patrick Müller
    A subset of the zebrafish Nodal receptor complex is regulated by positive feedback and controls the diffusion and distribution of Nodal signals during germ layer formation.
    1. Neuroscience

    A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila

    Tsai-Ning Li, Yu-Jung Chen ... Chi-Kuang Yao
    The interplay between the Flower Ca2+ channel and PI(4,5)P2 spatiotemporally couples synaptic vesicle exocytosis to activity-dependent bulk endocytosis and synaptic vesicle reformation from bulk endosomes.
    1. Developmental Biology

    Functional evolution of a morphogenetic gradient

    Chun Wai Kwan, Jackie Gavin-Smyth ... Urs Schmidt-Ott
    BMP guides the evolution of extraembryonic tissue complexity in fly embryos through changes in the control of a positive feedback circuit.
    Short Report Updated
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    1. Developmental Biology

    Positive feedback regulation of frizzled-7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

    Takayoshi Yamamoto, Yuta Kambayashi ... Stefan Hoppler
    Biomolecular experiments and computer simulations revealed that morphogen receptors expressed via a positive feedback loop impart robustness against variations in morphogen secretion rate and speed of development.
    1. Neuroscience

    Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning

    Isaac Cervantes-Sandoval, Anna Phan ... Ronald L Davis
    Structural and functional analysis of axonal-axonal reciprocal connections between dopamine neurons and Kenyon cells provides insight into the brain computations for normal associative olfactory learning.

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