303 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

    Kevin G Hicks, Scott P Delbecq ... Samuel I Miller
    Receptor recognition of antimicrobial peptides is important for Salmonellae to survive inside macrophages and cause disease.
    1. Microbiology and Infectious Disease

    Dynamics of macrophage polarization support Salmonella persistence in a whole living organism

    Jade Leiba, Tamara Sipka ... Mai E Nguyen-Chi
    Real-time visualization of Salmonella enterica and polarized macrophage interaction in the living host identifies an anti-inflammatory, pro-regenerative, and motionless macrophage subset as a survival niche during persistent infection.
    1. Microbiology and Infectious Disease

    The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

    Stuti K Desai, Ricksen S Winardhi ... Linda J Kenney
    A response regulator acquired via lateral gene transfer has rewired an ancestral genetic circuitry and regulates alternative pathogenic lifestyles.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

    Megan E Carey, Zoe A Dyson ... Global Typhoid Genomics Consortium Group Authorship
    An analysis of the largest Salmonella Typhi genome collection to date (n=13,000) provides an updated overview of global genome diversity and antimicrobial resistance trends over time to inform public health action.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Rapid geographical source attribution of Salmonella enterica serovar Enteritidis genomes using hierarchical machine learning

    Sion C Bayliss, Rebecca K Locke ... Lauren A Cowley
    Application of hierarchical machine learning to the geographical source attribution of Salmonella enteritidis indicates high utility for the rapid translation of raw pathogen genome sequencing data into accurate and actionable information for disease management in public health.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A pH-sensitive switch activates virulence in Salmonella

    Dasvit Shetty, Linda J Kenney
    A single conserved residue – histidine 12 – confers pH-sensitive DNA binding to the Salmonella Typhimurium SPI-2 transcriptional regulator SsrB, thereby regulating Salmonella virulence.
    1. Microbiology and Infectious Disease

    Structural basis of host recognition and biofilm formation by Salmonella Saf pili

    Longhui Zeng, Li Zhang ... Guoyu Meng
    SafDAA-SafDAA structure and functional characterizations reveal a pili-mediated inter-cellular oligomerization mechanism for bacterial aggregation and biofilm formation in Salmonella enterica.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Fitness benefits in fluoroquinolone-resistant Salmonella Typhi in the absence of antimicrobial pressure

    Stephen Baker, Pham Thanh Duy ... Maciej F Boni
    The major evolutionary routes to drug resistance in Salmonella Typhi are associated with fitness benefits, not fitness costs, implying that prudent antimicrobial use will have no effect as a public health intervention in controlling typhoid fever.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Apoptotic signaling clears engineered Salmonella in an organ-specific manner

    Taylor J Abele, Zachary P Billman ... Edward A Miao
    Clearance of engineered Salmonella which trigger regulated cell death is dependent upon the cellular 'bucket list,' which is determined both by cell death signaling pathway and by cell type infected.
    1. Microbiology and Infectious Disease

    Genetic code expansion enables visualization of Salmonella type three secretion system components and secreted effectors

    Moirangthem Kiran Singh, Parisa Zangoui ... Linda J Kenney
    Genetic code expansion (GCE) enables site-specific labeling and visualization of Salmonella secreted effectors, secretion system components and provides a viable alternative for labeling proteins that do not tolerate N- or C-terminal tags.

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