98 results found
    1. Neuroscience

    Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release

    Paul F Kramer, Emily L Twedell ... Zayd M Khaliq
    GABA-A receptors on dopamine neuron axons not only depolarize the membrane but also limit action potential propagation, an effect potentiated by positive allosteric modulators of GABA-A receptors like diazepam (Valium).
    1. Neuroscience

    GABAergic inhibition in human hMT+ predicts visuo-spatial intelligence mediated through the frontal cortex

    Yuan Gao, Yong-Chun Cai ... Xue Mei Song
    Information exchange between the sensory cortex (hMT+) and cognition core (BA46), coupled with hMT+ GABA levels, predicts performance in 3D visuo-spatial ability.
    1. Neuroscience

    REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

    Cosimo Prestigio, Daniele Ferrante ... Pietro Baldelli
    A combination of electrophysiological, immunocytochemical, and biochemical approaches elucidate the mechanisms by which the transcriptional regulator REST/NRSF rescues neuronal homeostasis by upregulating GABAergic transmission selectively onto excitatory neurons in response to hyperactivity.
    1. Genetics and Genomics

    Neuroendocrinology of the lung revealed by single-cell RNA sequencing

    Christin S Kuo, Spyros Darmanis ... Mark A Krasnow
    Single-cell transcriptomic profiling and systematic analysis of pulmonary neuroendocrine cells identifies over 40 hormones and neuropeptides expressed in myriad combinations, and predicts their targets in mouse and human lung, revealing extraordinary sensory and signaling diversity and potential physiological functions.
    1. Neuroscience

    The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies

    Eric C Porges, Greg Jensen ... Nicolaas AJ Puts
    Individual participant data meta-analysis reveals the estimated lifespan trajectory of cortical GABA, characterized by an early rapid increase, followed by a period of stability during early adulthood, and a gradual decrease.
    1. Neuroscience

    The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice

    Camille Dumon, Diabe Diabira ... Jean-Luc Gaiarsa
    Maternal obesity and excess of the adipocyte hormone leptin delays the emergence of synaptic inhibition in the developing brain mice.
    1. Microbiology and Infectious Disease

    Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract

    Valérie Laroute, Catherine Beaufrand ... Muriel Cocaign-Bousquet
    Generally recognised as safe GABA-producing L. lactis strains could be considered as future therapeutic agents for the management of visceral pain and the anxious profile of IBS patients.
    1. Plant Biology

    Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

    Yaron Caspi, Chrysoula K Pantazopoulou ... Kaisa Kajala
    Recent findings about the possible intercellular signalling role of glutamate, GABA, and melatonin might help to establish hypotheses concerning the evolutionary factors that caused intercellular organisms to use specific molecules in intercellular signalling.
    1. Neuroscience

    Mapping responses to focal injections of bicuculline in the lateral parafacial region identifies core regions for maximal generation of active expiration

    Annette Pisanski, Mitchell Prostebby ... Silvia Pagliardini
    Multivariate analysis of respiratory cycle shows that GABAergic disinhibition in the rostral regions of the lateral parafacial area is linked to the most significant and enduring changes in active expiration.
    1. Neuroscience

    An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans

    Yu Shen, Quan Wen ... Yun Zhang
    The activity of a set of GABAergic neurons is causally linked with a locomotory pattern in moving animals, and the mechanisms underlying the neuromodulatory role of GABA are illuminated.

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