Single-cell RNA-sequencing unraveled cell subtype-specific transcriptomic changes in both injured and uninjured primary sensory neurons after nerve injury and demonstrated transcriptomic sexual dimorphism.

Sodium-activated potassium ion currents encoded by the kcnt1 gene delay action potential firing in DRG neurons by activity preceding an action potential.

The molecular, cellular, and spatial heterogeneity of adult human spinal cord serve as an important resource to explore the mechanisms underlying spinal cord physiology and diseases.

Inhibiting RNA N6-methyladenosine demethylase ALKBH5 promoted axonal regeneration of dorsal root ganglion neurons by regulating stability of Lpin2 mRNA and enhanced the survival and axonal regeneration of retinal ganglion cells.

Molecular analysis paints a detailed picture of the distinctiveness and complexities of peripheral somatosensory neurons.

TRPM3 inhibition is identified as a novel mechanism for G-protein βγ subunit signalling.

The microenvironment surrounding sensory neurons in dorsal root ganglia responds differently to peripheral and central injuries, revealing that non-neuronal cells can be manipulated to promote axon regeneration after central injury.

Proteomic analyses reveal a distinct protein signature underlying microtubule organization and regenerative asymmetries in sensory neuron axons, supported by an in vitro system replicating key features of sensory neuron biology.

Cis and trans activation of the receptor tyrosine kinase RET lead to similar biological outcomes in rapidly adapting mechanoreceptors in vivo.

Single-nucleus transcriptomics exposes unique features of human somatosensory neurons and clues that may help resolve repeated problems in translating new experimental approaches for treating pain.